Accelerated Partial Breast Irradiation: Techniques and Clinical Implementation

Accelerated Partial Breast Irradiation: Techniques and Clinical Implementation, 9783540282020 (3540282025), Springer, 2006

Accelerated partial breast irradiation (APBI) is being rapidly introduced into the clinical management of early breast cancer. APBI, in fact, encompasses a number of different techniques and approaches that include brachytherapy, intraoperative, and external beam techniques. There is currently no single source that describes these techniques and their clinical implementation. This text will be a concise handbook designed to assist the clinician in the implementation of APBI. This will include a review of the principles that underlie APBI, a practical and detailed description of each technique for APBI, a review of current clinical results of APBI, and a review of the incidence and management of treatment related complications.

Results from two decades of study have conclusively shown that radiation therapy has an important role in ensuring local control for patients with early-stage breast cancer who are treated with breast-conserving surgery. When breast-conservation therapy was first explored as an alternative to mastectomy, many trials investigated whether surgical resection of the tumor-bearing region of the breast was sufficient, or whether adjuvant irradiation of the entire breast would be required to improve patient outcome. These trials showed that whole-breast irradiation significantly reduced the risk of ipsilateral tumor recurrence after resection of the tumor and the tissue immediately surrounding the tumor (Fisher et al. 2002a; Veronesi et al. 2001; Vinh-Hung and Verschraegen 2004).

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