Home | Amazing | Today | Tags | Publishers | Years | Account | Search 
Loading
Biology Of Genetic Dominance (Molecular Biology Intelligence Unit)

Buy
The word dominance, in the context of genetics, has been used for long time applied to characters or to alleles. A dominant character masks the expression of an alternative form. This loose definition would even apply when these alternatives are not determined by alleles of the same locus. In turn, a dominant allele refers to an alternative version at the same locus. This dual usage has led, as expected, to some confusion and shows how statistics can complement verbal definitions. Mendel, the pioneer of genetics, did not know the bases of the phenomenon of dominance.

Nor was he completely certain to look at characters defined by alleles. But the ubiquity of the phenomenon caused him to elevate his observations to the category of laws, that went, unfortunately, unnoticed until they were rediscovered decades later. Today, dominance and recessivity are concepts commonly used and not only by geneticists. Yet a question remains: do we really understand which are the mechanisms of dominance?

Dominance can be considered as a property of either characters or alleles in the living organisms. This must have an explanation in terms of their intrinsic architecture, which has been shaped by natural selection. To what extent dominance is a product of physiology or of evolution has been subject to much debate that is still ongoing. Classical genetics has considered dominance mainly as a result of intra-locus interactions. Indeed, simple mathematical models of positive and negative auto-regulatory circuits provide support to this notion. However, other models show that dominance can also result from the interaction of several loci (epistasis). This points to an intimate connection with epistasis, to such an extent that one can talk about epistatic dominance effects. Stemming from this, the word dominance in some parts of the text is not used with its classical meaning.

Dominance, from a phenomenological point of view, seems to have a general source: the existence of non-linear relationships between the genotypic and phenotypic values. However, the mechanisms generating these non-linearities are diverse. Models of gene expression, deterministic or stochastic, show the existence of strong non-linearities in the relationship between transactivator concentration and the product of transcription. The beautiful patterns of pigmentation of the butterfly wings are considered here as generated by stochastic processes producing sharp (sigmoidal) boundaries. However, similar events are probably underlying the action of transcription factors involved in developmental processes whose mutations are responsible for many human diseases.
(HTML tags aren't allowed.)

Enterprise Information Systems Assurance and System Security: Managerial and Technical Issues
Enterprise Information Systems Assurance and System Security: Managerial and Technical Issues
Few topics in the information technology (IT) field today generate as much interest as
security. Interestingly, the IT world has been struggling with security issues for over 30
years, yet many security problems remain unsolved, unaddressed, and serious. As
those responsible for securing systems and networks address security issues
...
Multimedia Systems: Algorithms, Standards, and Industry Practices
Multimedia Systems: Algorithms, Standards, and Industry Practices

Multimedia is now a broad “umbrella” that innovatively combines different fields of research and industry to produce practical solutions that are used on a wide scale today. Some of these fields are signal processing, imaging and color science, video and audio analysis, 2D/3D graphics, information theory, compression,...

SOA-Based Enterprise Integration: A Step-by-Step Guide to Services-based Application
SOA-Based Enterprise Integration: A Step-by-Step Guide to Services-based Application

Foreword by Ray Harishankar, IBM Fellow

"There are many books on the market on the topic of SOA and SOA's business and technology value. This book focuses on one of the key technical values of SOA and does an excellent job of describing SOA-based application integration by clarifying the relationship and patterns of SOA with other...


Fundamentals of Durable Reinforced Concrete (Modern Concrete Technology Series (E. & F.N. Spon).)
Fundamentals of Durable Reinforced Concrete (Modern Concrete Technology Series (E. & F.N. Spon).)
This book will be of particular interest to specifiers applying the principles of the new European Standard EN 206-1 for the first time; to postgraduate researchers in mathematical modeling of degradation mechanisms; to undergraduates of engineering, architecture, and building technology; and to students of advanced concrete technology who...
Training Guide: Administering Windows Server 2012
Training Guide: Administering Windows Server 2012

Designed to help enterprise administrators develop real-world, job-role-specific skills—this Training Guide focuses on deploying and managing Windows Server 2012. Build hands-on expertise through a series of lessons, exercises, and suggested practices—and help maximize your performance on the job.

This...

Getting Started with Digital Imaging, Second Edition: Tips, tools and techniques for photographers
Getting Started with Digital Imaging, Second Edition: Tips, tools and techniques for photographers
Whether you are using a digital compact or dSLR camera to shoot, or a Mac or PC to manipulate your images, Joe Farace explains what products are out thereand how to use them to get the best shots.

While most books offer photographers tips and tricks for working with the latest software package, this book offers a new approach to working
...
©2015 LearnIT (support@pdfchm.net) - Privacy Policy