Home | Amazing | Today | Tags | Publishers | Years | Account | Search 
Loading
Biology Of Genetic Dominance (Molecular Biology Intelligence Unit)

Buy
The word dominance, in the context of genetics, has been used for long time applied to characters or to alleles. A dominant character masks the expression of an alternative form. This loose definition would even apply when these alternatives are not determined by alleles of the same locus. In turn, a dominant allele refers to an alternative version at the same locus. This dual usage has led, as expected, to some confusion and shows how statistics can complement verbal definitions. Mendel, the pioneer of genetics, did not know the bases of the phenomenon of dominance.

Nor was he completely certain to look at characters defined by alleles. But the ubiquity of the phenomenon caused him to elevate his observations to the category of laws, that went, unfortunately, unnoticed until they were rediscovered decades later. Today, dominance and recessivity are concepts commonly used and not only by geneticists. Yet a question remains: do we really understand which are the mechanisms of dominance?

Dominance can be considered as a property of either characters or alleles in the living organisms. This must have an explanation in terms of their intrinsic architecture, which has been shaped by natural selection. To what extent dominance is a product of physiology or of evolution has been subject to much debate that is still ongoing. Classical genetics has considered dominance mainly as a result of intra-locus interactions. Indeed, simple mathematical models of positive and negative auto-regulatory circuits provide support to this notion. However, other models show that dominance can also result from the interaction of several loci (epistasis). This points to an intimate connection with epistasis, to such an extent that one can talk about epistatic dominance effects. Stemming from this, the word dominance in some parts of the text is not used with its classical meaning.

Dominance, from a phenomenological point of view, seems to have a general source: the existence of non-linear relationships between the genotypic and phenotypic values. However, the mechanisms generating these non-linearities are diverse. Models of gene expression, deterministic or stochastic, show the existence of strong non-linearities in the relationship between transactivator concentration and the product of transcription. The beautiful patterns of pigmentation of the butterfly wings are considered here as generated by stochastic processes producing sharp (sigmoidal) boundaries. However, similar events are probably underlying the action of transcription factors involved in developmental processes whose mutations are responsible for many human diseases.
(HTML tags aren't allowed.)

Predict Market Swings With Technical Analysis
Predict Market Swings With Technical Analysis
Predict Market Swings with Technical Analysis

How do professionals on Wall Street earn a living each year by predicting stock prices when efficient market theory claims that stock prices are essentially random and unpredictable? The answer is simple–by using techniques that allow for a stock market that can at times become predictable....

Software Measurement: Establish - Extract - Evaluate - Execute
Software Measurement: Establish - Extract - Evaluate - Execute
Our world and our society are shaped and increasingly governed by software. We might accept it or not, but it is happening at this point and will continue further on. It is difficult to imagine our world without software. There would be no running water, food supplies, business or transportation would disrupt immediately, diseases would spread, and...
Goddess of the Market: Ayn Rand and the American Right
Goddess of the Market: Ayn Rand and the American Right

Worshipped by her fans, denounced by her enemies, and forever shadowed by controversy and scandal, the novelist and philosopher Ayn Rand was a powerful thinker whose views on government and markets shaped the conservative movement from its earliest days. Drawing on unprecedented access to Rand's private papers and the original, unedited...


Professional Windows 8 Programming: Application Development with C# and XAML
Professional Windows 8 Programming: Application Development with C# and XAML
IT SEEMS LIKE YESTERDAY that Microsoft announced at its first annual BUILD conference the upcoming game-changing operating system: Windows 8. In the Microsoft world for the first time, Windows 8 was to provide an operating system that could create an ecosystem of apps that ran among phones, desktop computers, and tablets. Developers...
Inside Linux
Inside Linux
With in-depth complete coverage on the installation process, editing and typesetting, graphical user interfaces, programming system administration, and managing Internet sites, Inside Linux is the only book "smart users" new to Linux will need. Many of the users new to Linux have an understanding of computer technology and will be...
Eloquent JavaScript: A Modern Introduction to Programming
Eloquent JavaScript: A Modern Introduction to Programming

JavaScript is the language of the Web, and it's at the heart of every modern website from the lowliest personal blog to the mighty Google Apps. Though it's simple for beginners to pick up and play with, JavaScript is not a toy—it's a flexible and complex language, capable of much more than the showy tricks most...

©2012 LearnIT (support@pdfchm.net) - Privacy Policy