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DNA Repair in Cancer Therapy (Cancer Drug Discovery and Development)

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The field of DNA repair has been the subject of increasing interest at both the genetic and biochemical levels, leading to impressive progress in this area. DNA repair and its associated regulatory mechanisms lie at the heart of almost every fundamental aspect of cell biology, including transcription, cell cycle, apoptosis, and development. Thanks to the fascinating investigations of the inherent gene defects of specific components of DNA repair pathways found in rare human syndromes (e.g., xeroderma pigmentosum), we have been provided with the framework for subsequent studies on the translational aspects of DNA repair. Several genes have been cloned, and the crystal structures of some proteins are now reported. Polymorphisms in certain of the DNA repair genes are being identified in human populations. Furthermore, increased research efforts highlight the involvement of DNA repair mechanisms in the maintenance of genomic stability, mutagenesis and carcinogenesis, and resistance to endogenous and exogenous genotoxic stress.

In preparing DNA Repair in Cancer Therapy, we have been concerned with those practicing oncologists who are dealing on a daily basis with the hallmark “relapse” or “drug resistance” phenomena. Among the multifactorial mechanisms described so far, there is increasing evidence that impaired expression/ activity of at least some of the DNA repair proteins can account for tumor cell resistance to a particular therapeutic agent. Further interest has been stimulated by the demonstration that DNA repair is coupled to cell cycle checkpoint controls which, when impaired, could account for clinical drug resistance. Surprisingly, there have been relatively few comprehensive review articles and, as far as we know, no complete volume dedicated to the translational aspect of DNA repair in the clinic. This fostered the need to organize a set of timely, in-depth reviews covering the latest developments having potential for translational and clinical applications.
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Small Universal Cellular Automata in Hyperbolic Spaces: A Collection of Jewels
Small Universal Cellular Automata in Hyperbolic Spaces: A Collection of Jewels

Hyperbolic geometry is an essential part of theoretical astrophysics and cosmology. Besides specialists of these domains, many specialists of new domains start to show a growing interest
both to hyperbolic geometry and to cellular automata. This is especially the case in biology and computer science.

This book gives the...

iPhone SDK Development
iPhone SDK Development
Packing the power of desktop applications into a small mobile device, the iPhone SDK offers developers the ability to create dynamic, visually-appealing, and highly-capable mobile applications, using the same APIs and tools that Apple uses for its own applications.

However, harnessing that power means learning new tools, new APIs,
...
A Concise Introduction to Data Compression (Undergraduate Topics in Computer Science)
A Concise Introduction to Data Compression (Undergraduate Topics in Computer Science)
Compressing data is an option naturally selected when faced with problems of high costs or restricted space. Written by a renowned expert in the field, this book offers readers a succinct, reader-friendly foundation to the chief approaches, methods and techniques currently employed in the field of data compression.

Part I presents the basic...


Evolution For Dummies (Math & Science)
Evolution For Dummies (Math & Science)
Today, most colleges and universities offer evolutionary study as part of their biology curriculums. Evolution For Dummies will track a class in which evolution is taught and give an objective scientific view of the subject. This balanced guide explores the history and future of evolution, explaining the concepts and science behind it,...
Proceedings of International Ethical Hacking Conference 2019: eHaCON 2019, Kolkata, India (Advances in Intelligent Systems and Computing)
Proceedings of International Ethical Hacking Conference 2019: eHaCON 2019, Kolkata, India (Advances in Intelligent Systems and Computing)

This book gathers the peer-reviewed proceedings of the International Ethical Hacking Conference, eHaCON 2019, the second international conference of its kind, which was held in Kolkata, India, in August 2019. Bringing together the most outstanding research papers presented at the conference, the book shares new findings on computer...

Stochastic Optimal Control and the U.S. Financial Debt Crisis
Stochastic Optimal Control and the U.S. Financial Debt Crisis

Stochastic Optimal Control (SOC)—a mathematical theory concerned with minimizing a cost (or maximizing a payout) pertaining to a controlled dynamic process under uncertainty—has proven incredibly helpful to understanding and predicting debt crises and evaluating proposed financial regulation and risk...

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