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Molecular Basis of Thyroid Cancer (Cancer Treatment and Research)

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Thyroid cancer is the fastest growing cancer in the U.S., especially among women. Given the relative success we have had in its treatment, there is a need to capitalize on it by better understanding the factors that underpin this malignancy, and exploring better strategies for diagnosis, treatment, and follow-up. To do so, we must take full advantage of the revolution in modern biology.

This comprehensive volume addresses the needs of a broad readership. Against a backdrop of the complexity of the origins of cancer, pathology of thyroid tumors, including lymphomas, is discussed, as are molecular genetic lesions associated with spontaneous and radiation-related thyroid tumors, diagnostic tests available to surmise tumor subtypes (including a review of the potential of DNA micro arrays), advances in therapeutics (including recombinant hTSH superagonists, allowing for better treatment of well differentiated thyroid carcinoma and its imaging), and combinations of drugs that might influence the course of poorly differentiated and anaplastic thyroid cancer. In this book, we glimpse into the promise of gene therapy in the future management of otherwise lethal anaplastic and poorly differentiated thyroid tumors. The molecular genetics of medullary thyroid cancer is considered in depth, and malignancy is used as a showcase for genetic prediction and counseling.

The Molecular Basis of Thyroid Cancer is an indispensable companion for endocrinologists (particularly those with an interest in thyroid cancer), thyroid surgeons, nuclear medicine physicians, molecular oncologists, clinical biochemists, and those in biotechnology intent on the innovation of better diagnosis and therapy of cancer.

I am fortunate and privileged to be the editor of The Molecular Basis of Thyroid Cancer. I compiled a list of top scientists based on their areas of expertise in thyroid cancer whom I hoped would contribute, and received enthusiastic and positive responses. Their chapters are superb.

Throughout this project I have been supported and advised by two wonderful individuals from Kluwer: the untiring Maureen Tobin, editorial assistant and Laura Walsh, editor. They have made the task of putting this book together a pleasure.
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