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The year 2006 is the centenary of Alois Alzheimer’s presentation to a meeting of German
psychiatrists held in Tübingen, Germany. In 1906, Alzheimer described the results of his
studies on a female patient known as Auguste D., who had suffered from a progressive presenile
dementia. In 1907, Alzheimer published this study in a paper entitled “Über eine
eigenartige Erkrankung der Hirnrinde” in Allgemeine Zeitschrift für Psychiatrie und
psychisch-gerichtliche Medizin. This paper was a landmark in our understanding of the
disease that now bears his name. The paper described the major lesions that are now
known to be common to all forms of Alzheimer’s disease.
After 100 years it is time to reflect upon the enormous progress that has been made since
Alois Alzheimer’s first observations were reported. The chapters within this book describe
some of the major conceptual advances of the last few years, particularly in understanding
Alzheimer’s disease pathogenesis, and the research that may lead to successful therapies.
Central to the story of Alzheimer’s disease is the β-amyloid protein or Aβ, a 4-kDa
polypeptide that is intimately involved in the pathogenic cascade. Increasingly it is
recognized that Aβ is a causative agent that plays a key role in disease pathogenesis.
The chapters in this book are written by experts in their respective fields, and each
author provides individual insight into the role of Aβ in the pathogenesis of Alzheimer’s
disease. The chapters contain innovative ideas on the biochemical, cellular, and behavioral
pathogenesis of Alzheimer’s disease that should propel research over the next few years. |
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 Ruby on Rails Web Mashup ProjectsA web mashup is a new type of web application that uses data and services from one or more external sources to build entirely new and different web applications. Web mashups usually mash up data and services that are available on the Internet—freely, commercially, or through other partnership agreements. The external sources that a mashup... | | Medical Data ManagementCareful documentation is essential in all fields of medicine and health care, whether it may serve the treatment of patients, compliance with legal obligations, reimbursement and cost analysis, quality assurance, or clinical research. Clinical documentation must be conducted in a systematic way; otherwise, there is a danger of it becoming a... | | Urogynecology: Evidence-Based Clinical Practice
With rising prevalence of urinary incontinence and prolapse in aging population in the Western world there is an increasing need for knowledge about this subject. This handy pocketbook summarizes the practical patient management, based upon the available evidence and author’s own clinical experience, and indicates controversial areas... |
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