Dr. Burke Cunha, one of the foremost experts in the field of infectious disease, has put together an outstanding comprehensive issue with an exceptional team of authors that covers the most important updates in antimicrobial therapy. Treatment of helicobacter pylori, clostridium difficile, macrolide resistant S. pneumonia, and serious systemic infectious is covered. Authors discuss a clinical approach to anitibiotic failure, prevention and control of resistance, drug interactions, and therapy in the penicillin allergic patient. Monotherapy versus combination therapy, bacteriostatic versus bactericidal therapy, and in vitro susceptibility testing versus in vivo effectiveness are also covered. The issue also updates the reader on new uses for older antibiotics.