The aim of Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms
is to present recent developments in cell survival and apoptotic pathways and
their involvement in human diseases, such as cancers and neurodegenerative disorders.
This requires an integration of knowledge from several fields of research, including
pathology, genetics, virology, cell biology, medicine, immunology, and molecular
biology. This edition of the book examines the impact of molecular biology on disease
mechanisms. With recent advances in technology such as microarray and proteomics,
new biomarkers and molecular targets have been identified. These potential
targets will be very useful for the development of novel and more effective drugs for
the treatment of human diseases. The challenge now is not only to understand disease
mechanisms but also to apply this knowledge to find therapies that are more effective.
Cellular processes play major roles in cell survival and apoptosis. These events
are essential for tissue homeostasis and the maintenance of proper growth and development
of multicellular organisms. Imbalance in survival and apoptotic pathways may
lead to several diseases. Therefore, understanding the molecular mechanisms of cell
survival and apoptotic pathways is essential for the treatment and prevention of human
diseases. The main focus of Apoptosis, Cell Signaling, and Human Diseases:
Molecular Mechanisms is to discuss the recent development in cell signaling events,
growth, metastasis, and angiogenesis, mechanisms of drug resistance, and targeted
therapy for human diseases. Volume 1 contains 15 chapters divided into two sections:
“Malignant Transformation and Metastasis” and “Molecular Basis of Disease Therapy”;
Volume 2 contains 18 chapters, also divided into two sections: “Kinases and Phosphatases”
and “Molecular Basis of Cell Death.” Scientists well known in their fields
have contributed to this book.