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The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available antibiotics, and requires new approaches to antibiotic discovery and development. Antimicrobial resistance can be acquired in a short time frame, both by genetic mutation and by direct transfer of resistance genes across genus and species boundaries. Understanding mechanisms of resistance is crucial to the future of antimicrobial therapy.
Extensively revised, with contributions from international leaders in their fields, Bacterial Resistance to Antimicrobials, Second Edition blends scientific and practical approaches to the social, economic, and medical issues related to this growing problem. The book begins with a history of antimicrobial agents and bacterial resistance, and outlines the forces that contributed to the abuse of antibiotics and precipitated the current crisis. It goes on to describe what is known about the ecology of antibiotic resistant bacteria and reveals the inadequacies in our understanding. Emphasizing public health aspects, the editors stress that significant progress will be made only by addressing the problem only as a public, worldwide, problem.
Chapters on resistance mechanisms describe the latest findings on what makes different groups of bacteria susceptible or resistant to antibiotics. They reveal the staggering diversity of bacteria and the need for a foundational understanding that will stimulate development of antibiotics capable of avoiding resistance mechanisms. Examining the success and limitations of complementary approaches, such as combining ß-lactam antibiotics with ß-lactamase inhibitors, the book brings together information on resistance mechanisms in different groups of bacteria to help future efforts to more effectively develop and deploy antimicrobial therapies. |
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Photoshop 7 in No TimeThis is a book about Photoshop 7. Photoshop is Adobe’s venerable imageediting software, the darling of creative professionals everywhere. With Photoshop, you can prepare artwork for print and the Web, create and edit pixel-based graphics, repair damaged photographs, apply special effects, and convert graphics files from one format to another.... | | | | |
How We Cooperate: A Theory of Kantian Optimization
A new theory of how and why we cooperate, drawing from economics, political theory, and philosophy to challenge the conventional wisdom of game theory
Game theory explains competitive behavior by working from the premise that people are self-interested. People don’t just compete, however; they also ... | | Pro Crystal Enterprise / BusinessObjects XI ProgrammingPro Crystal Enterprise/BusinessObjects XI Programming shows you how to create customized solutions using the Business Objects/Crystal Enterprise object model. Here youll see the object model utilized to create professional-quality tools like on-demand web services, report metadata extraction, scheduling, security, and user... | | The Basics of Financial Modeling
The ability to create and understand financial models that assess the valuation of a company, the projects it undertakes, and its future earnings/profit projections is one of the most valued skills in corporate finance. However, while many business professionals are familiar with financial statements and accounting reports, few are truly... |
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