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Brain Tumors (Contemporary Cancer Research)

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Exciting new developments and discoveries of the last two decades are beginning to shed light on the complex biology of brain tumors and are advancing our understa- ing of the cellular and molecular processes involved in their initiation, progression, and clinical and biological behavior. The disease process in brain tumors is quite complex and the resulting tumors are characterized by a high degree of biological and clinical diversity. Thus, despite the advances of the last two decades, prognosis for patients with malignant brain tumors remains abysmal. Significant progress in the diagnosis, treatment and, ultimately, prevention of these tumors will require both the timely h- nessing of the advances in basic and clinical brain tumor research, and a continuing concerted effort at increasing our understanding of brain tumor biology, in particular, the molecular genetic changes and perturbations of cellular pathways involved in brain oncogenesis and which drive the biological and clinical behavior of the tumors. Brain tumor diagnosis and prognosis, which is still largely based on histopathology and other clinical criteria, will, in the future, acquire a significant molecular component, with the incorporation of knowledge of genes that are mutated, over-expressed, deleted, silenced, or functionally altered in the tumors. Treatment strategies for brain tumors, rather than being empirical, will be rationally developed based on an understanding of the cellular and molecular mechanisms and targets that have been activated, suppressed, or otherwise altered.

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The Joy of Clojure: Thinking the Clojure Way
The Joy of Clojure: Thinking the Clojure Way

The authors of this book have taken an ambitious and aggressive approach to teaching Clojure. You know how everyone loves to say they teach using the “drinking from a fire hydrant” method? Well, at times it feels like these guys are trying to shove that fire hydrant right up... let’s just say it’s a place...

Cryptanalysis of RSA and Its Variants
Cryptanalysis of RSA and Its Variants

Thirty years after RSA was first publicized, it remains an active research area. Although several good surveys exist, they are either slightly outdated or only focus on one type of attack. Offering an updated look at this field, Cryptanalysis of RSA and Its Variants presents the best known mathematical attacks on RSA and its...

C: An advanced introduction (Principles of computer science series)
C: An advanced introduction (Principles of computer science series)
The C programming language was designed and implemented by Dennis Ritchie in 1972 at AT&T Bell Laboratories. Despite a late start, the popularity of C has been increasing rapidly. C compilers are now available for many machines and the list of available C compilers is growing fast [Halfant 1983, Kern 1983, Phraner 1983]. Two important reasons...

Five-Star Apps: The best iPhone and iPad apps for work and play
Five-Star Apps: The best iPhone and iPad apps for work and play

What makes a five-star app? A program has to be interesting, even if the task it’s performing is routine. When you look at a dozen apps that have the same informational, utilitarian, or entertainment goal, five-star apps have that extra something special that floats to the top.

It can be a concierge, camera, flashlight, game...

Book: A Futurist's Manifesto: A Collection of Essays from the Bleeding Edge of Publishing
Book: A Futurist's Manifesto: A Collection of Essays from the Bleeding Edge of Publishing

The ground beneath the book publishing industry dramatically shifted in 2007, the year the Kindle and the iPhone debuted. Widespread consumer demand for these and other devices has brought the pace of digital change in book publishing from "it might happen sometime" to "it’s happening right now"—and it...

Agile Web Development with Rails: A Pragmatic Guide (Pragmatic Programmers)
Agile Web Development with Rails: A Pragmatic Guide (Pragmatic Programmers)

Rails is a full-stack, open source web framework that enables you to create full-featured, sophisticated web-based applications, but with a twist... A full Rails application probably has less total code than the XML you'd need to configure the same application in other frameworks. With this book you'll learn how to use...

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