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Cancer Drug Resistance (Cancer Drug Discovery and Development)

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Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

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WALCOM: Algorithms and Computation: Second International Workshop, WALCOM 2008, Dhaka, Bangladesh, February 7-8, 2008, Proceedings (Lecture Notes in Computer Science)
WALCOM: Algorithms and Computation: Second International Workshop, WALCOM 2008, Dhaka, Bangladesh, February 7-8, 2008, Proceedings (Lecture Notes in Computer Science)

This book constitutes the refereed proceedings of the Second International Workshop on Algorithms and Computation, WALCOM 2008, held in Dhaka, Bangladesh, in February 2008.

The 19 revised full papers presented together with 3 invited papers were carefully reviewed and selected from 57 submissions. The papers feature...

Hierarchical Neural Networks for Image Interpretation (Lecture Notes in Computer Science)
Hierarchical Neural Networks for Image Interpretation (Lecture Notes in Computer Science)

It is my pleasure and privilege to write the foreword for this book, whose results I have been following and awaiting for the last few years. This monograph represents the outcome of an ambitious project oriented towards advancing our knowledge of the way the human visual system processes images, and about the way it combines high...

Strategic Negotiation : A Breakthrough Four-Step Process for Effective Business Negotiation
Strategic Negotiation : A Breakthrough Four-Step Process for Effective Business Negotiation

We all know that the business environment changes every day. But the radical shift that’s taken place in negotiating in recent years is so substantial that it requires an equally radical shift in thinking. Looking at negotiation as a series of tactics simply won’t work anymore. The only way you can meet the challenges of negotiating...


Data-Driven Security: Analysis, Visualization and Dashboards
Data-Driven Security: Analysis, Visualization and Dashboards

Uncover hidden patterns of data and respond with countermeasures

Security professionals need all the tools at their disposal to increase their visibility in order to prevent security breaches and attacks. This careful guide explores two of the most powerful ? data analysis and visualization. You'll soon understand how to...

Java After Hours : 10 Projects You'll Never Do at Work
Java After Hours : 10 Projects You'll Never Do at Work

Take your Java programming skills beyond the ordinary. Java After Hours: 10 Projects You'll Never Do at Work will make Java your playground with ten detailed projects that will have you exploring the various fields that Java offers to build exciting new programs. You'll learn to:

Switching to the Mac: The Missing Manual, Mountain Lion Edition (Missing Manuals)
Switching to the Mac: The Missing Manual, Mountain Lion Edition (Missing Manuals)

Ready to move to the Mac? This incomparable guide helps you make a smooth transition. New York Times columnist and Missing Manuals creator David Pogue gets you past three challenges: transferring your stuff, assembling Mac programs so you can do what you did with Windows, and learning your way around OS X.

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