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Cardiac Gene Expression: Methods and Protocols (Methods in Molecular Biology)

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This book presents both cutting-edge and established methods for studying cardiac gene expression. The protocols provide a template for solid research, and cover the process through screening, analysis, characterization, and functional confirmation of novel genes or known genes with a new function. The concluding section of the book highlights methods that facilitate overexpression or cardiac-specific targeted gene deletion.

The past decade has ushered in enormous changes in how we perceive and study changes in gene expression in the heart. Early in the 1990s, the human genome project was just getting underway and establishing methods with the sensitivity to measure changes in the expression of genes with low copy number was an accomplishment. We all experienced some trepidation when the first news of microarrays arrived espousing the ability to measure changes in expression of hundreds to tens of thousands of genes (the whole genome) at once. This high throughput method was an astonishing jump in our approach to biological science. At the same time Steve Fodor and Pat Brown published papers describing two completely different approaches to measuring the expression changes of large numbers of genes at the same time. Thus began the microarray era and as a consequence the beginning of an era with a host of new approaches in pursuit of understanding the role and regulation of gene expression in cell biology and pathology including driving forward the field of bioinformatics.

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Fault Tolerant Control for Switched Linear Systems (Studies in Systems, Decision and Control)
Fault Tolerant Control for Switched Linear Systems (Studies in Systems, Decision and Control)

This book presents up-to-date research and novel methodologies on fault diagnosis and fault tolerant control for switched linear systems. It provides a unified yet neat framework of filtering, fault detection, fault diagnosis and fault tolerant control of switched systems. It can therefore serve as a useful textbook for senior and/or graduate...

Blogging For Dummies
Blogging For Dummies

This proven bestseller is fully updated and better than ever!

Now in its fourth edition, Blogging For Dummies is fully updated and more practical than ever for today's bloggers. Whether you're just beginning or are already a full-tilt blogging maven, you'll find the up-to-date information you need in these...

Pattern Recognition and Classification: An Introduction
Pattern Recognition and Classification: An Introduction

The use of pattern recognition and classification is fundamental to many of the automated electronic systems in use today. However, despite the existence of a number of notable books in the field, the subject remains very challenging, especially for the beginner.

Pattern Recognition and Classification presents a comprehensive
...


Machine Learning Methods in the Environmental Sciences: Neural Networks and Kernels
Machine Learning Methods in the Environmental Sciences: Neural Networks and Kernels
Machine learning is a major subfield in computational intelligence (also called artificial intelligence). Its main objective is to use computational methods to extract information from data. Neural network methods, generally regarded as forming the first wave of breakthrough in machine learning, became popular in the late 1980s, while kernel...
Angel Capital: How to Raise Early-Stage Private Equity Financing (Wiley Finance)
Angel Capital: How to Raise Early-Stage Private Equity Financing (Wiley Finance)
The number one concern of start-up entrepreneurs and growing small business
owners and managers is how to finance their venture. When the personal
financial resources of the entrepreneur are exhausted, when the
tradition of going to family and friends for “cradle equity” has been thoroughly
“worked,” and
...
ITIL Version 3 at a Glance: Information Quick Reference
ITIL Version 3 at a Glance: Information Quick Reference
ITIL® Version 3 At a Glance takes a graphical approach to consolidating the information of ITIL® version 3. ITIL® is an internationally-recognized set of best practices for providing IT service management. IT organizations worldwide are implementing ITIL® as a vehicle for improving IT service quality and improve...
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