|
Over the past few years, the power and potential of proteomics has become
widely recognized. The use of proteomics for the study of complex diseases is
increasing and is particularly applicable to cardiovascular disease, the leading
cause of death in developed countries. The ability to investigate the complete
proteome provides a critical tool toward elucidating the complex and multifactorial
basis of cardiovascular biology, especially disease processes. Proteomics
involves the integration of a number of technologies with the aim of analyzing
all the proteins expressed by a biological system in response to various stimuli
under different pathophysiological conditions. The proteomic approach offers
the ability to evaluate simultaneously the changes in protein expression and
cell signaling pathways in response to such conditions as atherosclerosis, cardiac
hypertrophy, stroke, or heart failure.
Cardiovascular Proteomics: Methods and Protocols covers many of the
above aspects of the proteomic approach in the cardiovascular field. This volume
takes the reader through the complete process of proteomic analysis, from
the obtention of specific heart proteins (troponin I) to the new techniques of
identifying risk biomarkers of atherome plaque rupture, analyzing the
secretome of explanted endarterectomies cultured in vitro, or the application of
phage display techniques to decipher the molecular diversity of blood vessels.
Determining global changes in the protein expression levels of cardiac
myocytes in response to states of ischemia, hypertension, hypertrophy, heart
failure, or infarction may disclose new molecules directly involved in these
pathologies. Thus, detailed protocols for the isolation and the short- and longterm
culture of adult mouse cardiac myocytes have been included. |
|
|
Complete Idiot's Guide to Tantric SexThe Complete Idiot's GuideA (R) to Tantric Sex covers every aspect of this ancient practice, from the sacred beliefs of Tantra which form the basis for Tantric loving to the process of preparing for and practicing Tantric techniques. The book is broken down into six parts, including: the secret sexual world of Tantra; preparing your mind for... | | Beginning SQL Server 2000 for Visual Basic Developers
This is the only book that provides comprehensive coverage of SQL Server 2000 specifically from a Visual Basic programmer's point of view. SQL Server is now the first choice for the Visual Basic developer who wants a more powerful, reliable, and sophisticated database than Microsoft Access can provide. SQL Server 2000 is tightly... | | Hardware and Software, Verification and Testing: Second International Haifa Verification Conference, HVC 2006, Haifa, Israel, October 23-26, 2006This book constitutes the thoroughly refereed post-proceedings of the Second International Haifa Verification Conference, HVC 2006, held in Haifa, Israel, in October 2006.
The 15 revised full papers presented together with 2 invited lectures were carefully reviewed and selected from 33 submissions. The papers are organized in three topical... |
|