Home | Amazing | Today | Tags | Publishers | Years | Account | Search 
Cell Death: Mechanism and Disease

Buy
Cell Death: Mechanism and Disease, 9781461493013 (1461493013), Springer, 2013

Beginning from centuries of anecdotal descriptions of cell death, such as those on the development of the midwife toad in 1842 by Carl Vogt, to modern-day investigations of cell death as a biological discipline, it has become accepted that cell death in multicellular organisms is a normal part of life. This book provides a comprehensive view of cell death, from its mechanisms of initiation and execution, to its implication in human disease and therapy.

Physiological cell death plays critical roles in almost all aspects of biology, and the book details its roles in lymphocyte homeostasis, neuronal function, metabolism, and the DNA damage response. When physiological cell death goes awry, diseases can arise, and cancer is presented as a central paradigm for the consequences of derangements in the interplay between cell survival and cell death. At the same time, the potential promise of targeted therapies aimed at interdicting cell death machineries are also discussed extensively. The molecular mechanisms that underlie apoptotic cell death are illustrated from the perspectives of both the intrinsic, mitochondrial apoptotic pathway and the extrinsic, death receptor pathway. Key players in these pathways, such as the Bcl2 family proteins, cytochrome c, Apaf-1, caspases, death receptor adapter proteins, and inhibitor of apoptosis proteins, are presented from both functional and structural angles. Until only a few years ago, programmed cell death has been considered essentially synonymous with apoptosis. However, we now know that programmed cell death can also take other forms such as necrosis or necroptosis, and to this end, the mechanisms that underlie programmed necrosis in development and host defense are illustrated. The past twenty plus years have seen an incredible growth of research in cell death, with one breakthrough after another, and the legacy still goes on with constant new surprises and findings. Long live cell death!

(HTML tags aren't allowed.)

Beginning PL/SQL: From Novice to Professional
Beginning PL/SQL: From Novice to Professional
This is a book about writing stored procedures for an Oracle database. A stored procedure in this context is a generic term for a program written in the Procedure Language extension for SQL (PL/SQL) that is stored inside the database when it is compiled. This means that you can then execute the program from inside the database. Why would you want...
Programming Windows With MFC
Programming Windows With MFC

Like many of my colleagues in this industry, I learned Windows programming from Charles Petzold's Programming Windows—a classic programming text that is the bible to an entire generation of Windows programmers. When I set out to become an MFC programmer in 1994, I went shopping for an MFC equivalent to Programming...

PEM Fuel Cell Durability Handbook, Two-Volume Set: PEM Fuel Cell Failure Mode Analysis
PEM Fuel Cell Durability Handbook, Two-Volume Set: PEM Fuel Cell Failure Mode Analysis

PEM Fuel Cell Failure Mode Analysis presents a systematic analysis of PEM fuel cell durability and failure modes. It provides readers with a fundamental understanding of insufficient fuel cell durability, identification of failure modes and failure mechanisms of PEM fuel cells, fuel cell component degradation testing, and...


Visualizing Information with Microsoft® Office Visio® 2007
Visualizing Information with Microsoft® Office Visio® 2007
Create and distribute data-connected Microsoft Office Visio diagrams and reports

Get full details on the powerful features of Microsoft Office Visio 2007 inside this comprehensive volume. Written by Visio expert David Parker, Visualizing Information with Microsoft Office Visio 2007 demonstrates how to effectively...

Model-Driven Architecture in Practice: A Software Production Environment Based on Conceptual Modeling
Model-Driven Architecture in Practice: A Software Production Environment Based on Conceptual Modeling
Formal specification languages, object-oriented methods, CASE tools, component-based software production, agent-oriented, aspect-oriented ... During the last two decades many techniques have been proposed from both research and industry in order to generate a correct software product from a higher-level system specification. Nevertheless, the many...
Synthesis and Optimization of Digital Circuits
Synthesis and Optimization of Digital Circuits

This new graduate textbook in computer engineering offers a modern, up-to-date look at computer aided design of VLSI circuits at the functional and logic level by addressing an interesting topic in CAD for digital circuits: design synthesis of detailed specifications from abstract models. Topics covered include hardware modeling, compilation...

©2018 LearnIT (support@pdfchm.net) - Privacy Policy