Home | Amazing | Today | Tags | Publishers | Years | Account | Search 
Cell Death: Mechanism and Disease

Buy
Cell Death: Mechanism and Disease, 9781461493013 (1461493013), Springer, 2013

Beginning from centuries of anecdotal descriptions of cell death, such as those on the development of the midwife toad in 1842 by Carl Vogt, to modern-day investigations of cell death as a biological discipline, it has become accepted that cell death in multicellular organisms is a normal part of life. This book provides a comprehensive view of cell death, from its mechanisms of initiation and execution, to its implication in human disease and therapy.

Physiological cell death plays critical roles in almost all aspects of biology, and the book details its roles in lymphocyte homeostasis, neuronal function, metabolism, and the DNA damage response. When physiological cell death goes awry, diseases can arise, and cancer is presented as a central paradigm for the consequences of derangements in the interplay between cell survival and cell death. At the same time, the potential promise of targeted therapies aimed at interdicting cell death machineries are also discussed extensively. The molecular mechanisms that underlie apoptotic cell death are illustrated from the perspectives of both the intrinsic, mitochondrial apoptotic pathway and the extrinsic, death receptor pathway. Key players in these pathways, such as the Bcl2 family proteins, cytochrome c, Apaf-1, caspases, death receptor adapter proteins, and inhibitor of apoptosis proteins, are presented from both functional and structural angles. Until only a few years ago, programmed cell death has been considered essentially synonymous with apoptosis. However, we now know that programmed cell death can also take other forms such as necrosis or necroptosis, and to this end, the mechanisms that underlie programmed necrosis in development and host defense are illustrated. The past twenty plus years have seen an incredible growth of research in cell death, with one breakthrough after another, and the legacy still goes on with constant new surprises and findings. Long live cell death!

(HTML tags aren't allowed.)

Absolute Beginner's Guide to Microsoft Office OneNote 2003
Absolute Beginner's Guide to Microsoft Office OneNote 2003
Absolute Beginner's Guide to Microsoft Office OneNote 2003 is a from-scratch reference that helps you get up to speed quickly on this new note taking and management program. The book starts from square one, explaining what OneNote is and why you would want to buy it. The book continues to show you how to type in...
Access Database Design & Programming: What You Really Need to Know to Develop with Access (Nutshell Handbooks)
Access Database Design & Programming: What You Really Need to Know to Develop with Access (Nutshell Handbooks)

When using software products with graphical interfaces, we frequently focus so much on the details of how to use the interface that we forget about the more general concepts that allow us to understand and put the software to effective use. This is particularly true of a powerful database product like Microsoft Access. Novice, and...

PHP Pocket Reference (Pocket Reference (O'Reilly))
PHP Pocket Reference (Pocket Reference (O'Reilly))

PHP is an open-source, HTML-embedded scripting language that allows you to handle tasks such as processing form input and working with databases directly in your HTML pages, rather than through CGI scripts.The PHP Pocket Reference is both a handy introduction to PHP syntax and structure and a quick reference to the vast array of...


Solving Applied Mathematical Problems with MATLAB
Solving Applied Mathematical Problems with MATLAB

This textbook presents a variety of applied mathematics topics in science and engineering with an emphasis on problem solving techniques using MATLAB®. The authors provide a general overview of the MATLAB language and its graphics abilities before delving into problem solving, making the book useful for readers without prior...

Information Modelling and Knowledge Bases XVII: Volume 136 Frontiers in Artificial Intelligence and Applications
Information Modelling and Knowledge Bases XVII: Volume 136 Frontiers in Artificial Intelligence and Applications
Information modelling and knowledge bases are becoming very important topics not only in academic communities related to information systems and computer science but also in the business field of information technology.

Currently, the structural complexity of information resources, the variety of abstraction levels of information, and
...
Rethinking Enterprise Storage: A Hybrid Cloud Model
Rethinking Enterprise Storage: A Hybrid Cloud Model
Just as the Internet has fundamentally changed many industries, cloud computing is fundamentally changing the information technology industry, including infrastructures such as enterprise data storage. This book is about one of the new infrastructure game changers—a storage architecture called hybrid cloud storage that was...
©2019 LearnIT (support@pdfchm.net) - Privacy Policy