Home | Amazing | Today | Tags | Publishers | Years | Account | Search 
Cell Death: Mechanism and Disease

Buy
Cell Death: Mechanism and Disease, 9781461493013 (1461493013), Springer, 2013

Beginning from centuries of anecdotal descriptions of cell death, such as those on the development of the midwife toad in 1842 by Carl Vogt, to modern-day investigations of cell death as a biological discipline, it has become accepted that cell death in multicellular organisms is a normal part of life. This book provides a comprehensive view of cell death, from its mechanisms of initiation and execution, to its implication in human disease and therapy.

Physiological cell death plays critical roles in almost all aspects of biology, and the book details its roles in lymphocyte homeostasis, neuronal function, metabolism, and the DNA damage response. When physiological cell death goes awry, diseases can arise, and cancer is presented as a central paradigm for the consequences of derangements in the interplay between cell survival and cell death. At the same time, the potential promise of targeted therapies aimed at interdicting cell death machineries are also discussed extensively. The molecular mechanisms that underlie apoptotic cell death are illustrated from the perspectives of both the intrinsic, mitochondrial apoptotic pathway and the extrinsic, death receptor pathway. Key players in these pathways, such as the Bcl2 family proteins, cytochrome c, Apaf-1, caspases, death receptor adapter proteins, and inhibitor of apoptosis proteins, are presented from both functional and structural angles. Until only a few years ago, programmed cell death has been considered essentially synonymous with apoptosis. However, we now know that programmed cell death can also take other forms such as necrosis or necroptosis, and to this end, the mechanisms that underlie programmed necrosis in development and host defense are illustrated. The past twenty plus years have seen an incredible growth of research in cell death, with one breakthrough after another, and the legacy still goes on with constant new surprises and findings. Long live cell death!

(HTML tags aren't allowed.)

Introduction to Nonlinear Dispersive Equations (Universitext)
Introduction to Nonlinear Dispersive Equations (Universitext)

The aim of this textbook is to introduce the theory of nonlinear dispersive equations to graduate students in a constructive way. The first three chapters are dedicated to preliminary material, such as Fourier transform, interpolation theory and Sobolev spaces. The authors then proceed to use the linear Schrodinger equation to describe...

Introduction to Systems Analysis & Design
Introduction to Systems Analysis & Design
Introduction to Systems Analysis and Design is intended to support a fi rst course in information systems development for information systems majors and other business majors.

We recommend that students take a computer or information systems literacy course before using this text. Introduction to Systems Analysis
...
Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition
Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition

Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research. Interpreting lessons learned from the clinical trials of first...


Microsoft SharePoint Technologies : Planning, Design and Implementation (HP Technologies)
Microsoft SharePoint Technologies : Planning, Design and Implementation (HP Technologies)
Microsoft SharePoint Technologies: Planning, Design and Implementation provides an in-depth examination of the tasks involved in planning, designing and deploying SharePoint in your enterprise. The book examines SharePoint from the user's perspective, the administrator's perspective, and the application developer's perspective and looks at how you...
Pro Java 6 3D Game Development: Java 3D, JOGL, JInput and JOAL APIs (Expert's Voice in Java)
Pro Java 6 3D Game Development: Java 3D, JOGL, JInput and JOAL APIs (Expert's Voice in Java)
Create strange lands filled with mysterious objects (cows frozen in blocks of ice, chirping penguins, golden globes with wavering eyes) and throw away your keyboard and mouse, to go exploring armed only with a gamepad, power glove, or just your bare hands…

Java gaming expert Andrew Davison will show you how to develop...

Problems and Solutions on Electromagneti (Major American Universities Ph.D. Qualifying Questions and Solutions)
Problems and Solutions on Electromagneti (Major American Universities Ph.D. Qualifying Questions and Solutions)
This series of physics problems and solutions, which consists of seven volumes — Mechanics, Electromagnetism, Optics, Atomic, Nuclear and Particle Physics, Thermodynamics and Statistical Physics, Quantum Me chanic, Solid State Physics and Relativity, contains a selection of 2550 problems from the graduate school entrance...
©2018 LearnIT (support@pdfchm.net) - Privacy Policy