Home | Amazing | Today | Tags | Publishers | Years | Account | Search 
Cell Line Development (Cell Engineering)

Buy

Mammalian cell lines command an effective monopoly for the production of therapeutic proteins that require post-translational modifications. This unique advantage outweighs the costs associated with mammalian cell culture, which are far grater in terms of development time and manufacturing when compared to microbial culture. The development of cell lines has undergone several advances over the years, essentially to meet the requirement to cut the time and costs associated with using such a complex hosts as production platforms.

This book provides a comprehensive guide to the methodology involved in the development of cell lines and the cell engineering approach that can be employed to enhance productivity, improve cell function, glycosylation and secretion and control apoptosis. It presents an overall picture of the current topics central to expression engineering including such topics as epigenetics and the use of technologies to overcome positional dependent inactivation, the use of promoter and enhancer sequences for expression of various transgenes, site directed engineering of defined chromosomal sites, and examination of the role of eukaryotic nucleus as the controller of expression of genes that are introduced for production of a desired product. It includes a review of selection methods for high producers and an application developed by a major biopharmaceutical industry to expedite the cell line development process. The potential of cell engineering approch to enhance cell lines through the manipulation of single genes that play important roles in key metabolic and regulatory pathways is also explored throughout.

(HTML tags aren't allowed.)

Fedora Core 7 & Red Hat Enterprise Linux: The Complete Reference
Fedora Core 7 & Red Hat Enterprise Linux: The Complete Reference
The Red Hat Linux and Fedora distributions have become one of the major Linux distributions, bringing to the PC all the power and flexibility of a Unix workstation as well as a complete set of Internet applications and a fully functional desktop interface. This book is designed not only to be a complete reference on Linux, but also to provide clear...
Urban and Regional Data Management: UDMS Annual 2013
Urban and Regional Data Management: UDMS Annual 2013

The Urban Data Management Society has organised international symposia at various locations throughout Europe since 1971, and UDMS 2013 marks its second visit to London. From its outset, UDMS has highlighted changes and trends in urban data and urban data management. However, the rate of emergence of new data and new technologies has never...

Coding for Penetration Testers: Building Better Tools
Coding for Penetration Testers: Building Better Tools

Coding for Penetration Testers: Building Better Tools, Second Edition provides readers with an understanding of the scripting languages that are commonly used when developing tools for penetration testing, also guiding users through specific examples of custom tool development and the situations where such tools might be used.

...


Microsoft SharePoint 2010 QuickSteps
Microsoft SharePoint 2010 QuickSteps

Step-by-Step, Full-Color Graphics!

Start using SharePoint 2010 right away--the QuickSteps way. Color screenshots and clear instructions make it easy to ramp up on the latest release of Microsoft's powerful collaboration platform. Follow along and quickly learn how to use a SharePoint site, add pages and web parts, create and...

Parallel Architectures and Bioinspired Algorithms (Studies in Computational Intelligence)
Parallel Architectures and Bioinspired Algorithms (Studies in Computational Intelligence)

This monograph presents examples of best practices when combining bioinspired algorithms with parallel architectures. The book includes recent work by leading researchers in the field and offers a map with the main paths already explored and new ways towards the future.

Parallel Architectures and Bioinspired Algorithms will be of...

Beginning Application Lifecycle Management
Beginning Application Lifecycle Management

Beginning Application Lifecycle Management is a guide to an area of rapidly growing interest within the development community: managing the entire cycle of building software. ALM is an area that spans everything from requirements specifications to retirement of an IT-system or application. Because its techniques allow you to deal...

©2019 LearnIT (support@pdfchm.net) - Privacy Policy