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Complex Systems and Computational Biology Approaches to Acute Inflammation

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The difficulty in achieving effective translation of basic mechanistic biomedical knowledge into effective therapeutics, is the greatest challenge in biomedical research. Nowhere is this more apparent than in the reductionist approaches to understanding and manipulating the acute inflammatory response in the settings of sepsis, trauma/hemorrhage, wound healing, and related processes. This book discusses complex systems and computational biology methods and approaches that have advanced sufficiently to allow for knowledge generation, knowledge integration, and clinical translation in the settings of complex diseases related to the inflammatory response. Well-regulated, self-resolving inflammation is necessary for the appropriate communication and resolution of infection and trauma, and for maintenance of proper physiology and homeostasis. In contrast, self-sustaining inflammation drives the pathobiology of the aforementioned diseases. It is now increasingly recognized that controlling and reprogramming inflammation in order to reap the benefits of this evolutionarily-conserved process is preferred to simply abolishing indiscriminately.

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Computational Chemistry: Reviews of Current Trends (Computational Chemistry: Reviews of Current Trends, Vol 6)
Computational Chemistry: Reviews of Current Trends (Computational Chemistry: Reviews of Current Trends, Vol 6)

There are strong indications that, in the 21st century, computational chemistry will be a prime research tool not only for the basic sciences but also for the life and materials sciences. Recent developments in nanotechnology allow us to detect a layer of single atoms. Researchers are able not only to image but also to manipulate molecules...

The Concept of Number: From Quaternions to Monads and Topological Fields (Mathematics and Its Applications)
The Concept of Number: From Quaternions to Monads and Topological Fields (Mathematics and Its Applications)
This book consists of lectures that I have given, in Darmstadt since 1974, under various titles, for beginners or students of the third semester.

I have tried to concentrate on those themes concerning numbers, which seem to me to be the most important on essential and historical grounds, and which in my opinion
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Common Statistical Methods for Clinical Research with SAS Examples, Third Edition
Common Statistical Methods for Clinical Research with SAS Examples, Third Edition

Aristotle, one of mankind’s greatest thinkers, rooted his basis of human understanding in the notion that universal phenomena can be explained through perception and rationalization. As such, Aristotle conjectured that a 10-pound object should fall through the air 10 times faster than a similar 1-pound object. This, and other intuitive...


Digital Games and Learning
Digital Games and Learning
Several years ago, I attended a conference in Shanghai that brought together leading American and Chinese thinkers about games and learning. The event’s organizers asked us to share what we saw as best practices from our respective countries. The Chinese game designers proudly displayed games that included historically...
LINQ for VB 2005
LINQ for VB 2005

Are you ready for the future of data access in .NET?

At the Microsoft Professional Developers Conference (PDC) 2005, Microsoft previewed a new technology, Language-Integrated Query (LINQ). It captured a lot of attention because it addressed the fundamental issue of merging object-oriented applications with relational data. The LINQ...

Integrating CMMI and Agile Development: Case Studies and Proven Techniques for Faster Performance Improvement
Integrating CMMI and Agile Development: Case Studies and Proven Techniques for Faster Performance Improvement

Many organizations that have improved process maturity through Capability Maturity Model Integration (CMMI®) now also want greater agility. Conversely, many organizations that are succeeding with Agile methods now want the benefits of more mature processes. The solution is to integrate CMMI and Agile....

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