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An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands. |
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The Handy Anatomy Answer Book (The Handy Answer Book Series)Pick up a magazine or newspaper, turn on the radio or television, or access medical and health information on the Internet and you will find that the human body is definitely in the news. Artificial hearts, dietary supplements, stem cell research, genetic engineering, arthroscopic surgery, and many other intriguing subjects on human biology and... | | | | |
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