Dipeptidyl Aminopeptidases: Basic Science and Clinical Applications (Advances in Experimental Medicine and Biology)

Dipeptidyl Aminopeptidases: Basic Science and Clinical Applications (Advances in Experimental Medicine and Biology), 9780387290584 (0387290583), Springer, 2006

DPP IV has been attributed a large array of functions, some of which are mediated by its exopeptidase activity. Although it only removes two amino acid residues at the N-terminus of the peptide, this cleavage can inactivate or modify the activity of regulatory peptides, peptide hormones, chemokines and neuropeptides. Several excellent DPP IV substrates with high specificity constants were identified by the in vitro kinetic study of the truncation of bioactive peptides by DPP IV. In vivo studies e.g. with DPP IV negative animals and in vivo inhibition experiments could enlighten us on the physiological relevance of these truncations.

The DPP IV mediated truncation of bioactive peptides has been reviewed on several occasions (Mentlein et al 1999, Lambeir et al 2003, De Meester et al 2000 and 2003). Here we want (1) to present some data on a novel DPP IV substrate, (2) to review some of the recent literature on known substrates and (3) to discuss the possible truncation of known DPP IV substrates by related dipeptidyl peptidases.

This is the first comprehensive volume on Dipeptidyl Aminopeptidases that can be marketed to a wide variety of disciplines, as well as to a variety of clinicians. Leading experts in the field contribute to this state-of-the-art view on these enzymes. This book comes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent.

Comments

Amazing Books

Learning iOS Programming: From Xcode to App Store

O'Reilly, 2013

The arrival of the iPhone changed everything. Or, at the very least, it changed the direction of software development for mobile platforms, which is a pretty big thing. It has spawned an entire generation of copycat devices and brought an entire multibilliondollar industry to its knees. Despite this, it still fits in...

High Strain Rate Behavior of Nanocomposites and Nanocoatings (SpringerBriefs in Materials)

Springer, 2015

This book describes the use of multiwall carbon nanotubes as composites with polycarbonates and as protective coatings on glass surfaces. The book explains fabrication and characterization methods for these composites and coatings. The author reports on the use of Split Hopkinson Pressure Bar set up for evaluating the dynamic...

Slow Light: Science and Applications (Optical Science and Engineering)

CRC Press, 2008

Exotic effects of slow light have been observed in the laboratory. But most currently available texts do not explore the wider field of slow light in photonic structures and optical fibers. Reflecting recent research, this book presents a comprehensive introduction to slow light and its potential applications, including storage, switching,...

The Billion Dollar BET: Robert Johnson and the Inside Story of Black Entertainment Television

John Wiley & Sons, 2004

Praise for The Billion Dollar BET

"This book provides insight into one of the great trailblazers of American business. Bob Johnson has been and continues to be an inspiration to me personally. He is a man who has persevered, overcome obstacles–personally and professionally–and has succeeded in spite of the challenges and...

Geometric Tools for Computer Graphics (The Morgan Kaufmann Series in Computer Graphics)

Morgan Kaufmann, 2002

Reinventing the wheel is a terrible waste of time, yet legions of computer programmers do exactly that every day. Geometric Tools for Computer Graphics gives the working graphics programmer a vast collection of programming examples, complex code snippets explained and ready to use. Each chapter is filled with more than just code...

Communication Systems Engineering (2nd Edition)

Prentice Hall, 2001

The objective of this book is to provide an introduction to the basic principles in the analysis and design of communication systems. It is primarily intended for use as a text for a first course in communications, either at a senior level or at a first-year graduate level.

Thorough coverage of basic digital communication...