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DNA Topoisomerases and Cancer (Cancer Drug Discovery and Development)

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DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include basic biochemical and structural reviews for the cancer-relevant topoisomerases. It will describe how topoisomerase dysfunctions can damage the genome and increase the risk of cancers, and the involvement of topoisomerases in programmed cell death. The book will also present the various topoisomerase inhibitors in clinical use and development and their molecular and cellular mechanisms of action.

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HTML5, JavaScript, and jQuery 24-Hour Trainer
HTML5, JavaScript, and jQuery 24-Hour Trainer

HTML5, the dominant web development technology, shares an ecosystem with CSS/CSS3, JavaScript, and JavaScript libraries like jQuery. To build robust, functional web applications, you need to understand these technologies and how they fit together. This book is your step-by-step, hands-on guide to building web apps.

Each section...

The Handy Weather Answer Book (The Handy Answer Book Series)
The Handy Weather Answer Book (The Handy Answer Book Series)
It is no exaggeration to say that weather affects everything we do in our lives. Weather influences how we dress, changes our plans for outdoor activities, cancels sporting events, closes airports, changes the course of wars, erodes mountains, destroys entire towns and cities, and has even been blamed for the death of U.S. President William Henry...
Urological Emergencies: A Practical Guide (Current Clinical Urology)
Urological Emergencies: A Practical Guide (Current Clinical Urology)

Practicing urologists and leading specialists summarize the optimal management of urgent and emergent urological conditions, so that physicians with limited urological training can take advantage of the incredible improvements in the management of acute urological problems. Up-to-date, evidence-based descriptions of the optimal diagnostic and...


Statistical Mechanics
Statistical Mechanics
Unlike most other texts on the subject, this clear, concise introduction to the theory of microscopic bodies treats the modern theory of critical phenomena. Provides up-to-date coverage of recent major advances, including a self-contained description of thermodynamics and the classical kinetic theory of gases, interesting applications such as...
What All Network Administrators Know
What All Network Administrators Know

This book is in response to the daily e-mails I receive from my website TheNetworkAdministrator, that ask the question; "What do I need to know to become a network administrator?" Some of you reading this book might find that you have all the qualifications needed, while others may become easily discouraged. Don’t be discouraged....

Awaken Healing Light of the Tao
Awaken Healing Light of the Tao

Included in this book are new spinal chi kung warmups to quickly energize any meditation. The reader will also learn how to combine sexual passion with a loving heart inside the body to relieve sexual-emotional frustration and speed up spiritual growth.

All Universal Tao books are based on the real experiences of the many people...

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