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Gene Engineering in Endocrinology (Contemporary Endocrinology)

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During the past five to ten years, a variety of tools has been developed in the disciplines of both gene engineering, and molecular and structural biology. Some of these advances have permitted scientists not only to identify and characterize genes, but also to target these genes by disruption, thus eliminating their function in living animals, and to det- mine the biological responses to altered gene products. This has particular significance in endocrine systems, in which feedback mechanisms between the hypothalamus, pi- itary, and end organs are critical in normal physiology. Interpretation of the physiological significance, or the site of action of specific molecules in this context, has been difficult prior to transgenic technology. Major advances have occurred specifically in the areas of growth and development, and of reproduction. Coupled with analysis of naturally occurring mutations in humans, the use of transgenic animals and in vitro systems has recently allowed endocrinologists to understand the importance of specific thyroid hormone receptor isoforms in vivo, the molecular basis for generalized resistance to thyroid hormones via mutations in the nuclear receptor, and mechanisms for suppressing gene transcription. Previously designated “orphan rec- tors,” such as steroidogenic factor-1, were demonstrated to have critical roles in dev- opment and reproduction. Other nuclear receptors―including those for thyroid hormone, estrogens, androgens, and progesterone―were shown to bind to coactivator and co- pressor proteins that modified their transcriptional activity, and contributed to the ce- specific effects of the hormones.

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The Evolution of Violence (Evolutionary Psychology)
The Evolution of Violence (Evolutionary Psychology)

This volume is an interdisciplinary exploration of our understanding of the causes and consequences of violence. Represented in its chapters are noted scholars from a variety of fields including psychology, anthropology, law, and literature. The contributions reflect a broad scope of inquiry and diverse levels of analysis. With an underlying...

Development of Professional Expertise: Toward Measurement of Expert Performance and Design of Optimal Learning Environments
Development of Professional Expertise: Toward Measurement of Expert Performance and Design of Optimal Learning Environments
Professionals such as medical doctors, airplane pilots, lawyers, and technical specialists find that some of their peers have reached high levels of achievement that are difficult to measure objectively. In order to understand to what extent it is possible to learn from these expert performers for the purpose of helping others improve their...
Professional Visual Studio 2005 Team System (Programmer to Programmer)
Professional Visual Studio 2005 Team System (Programmer to Programmer)
The launch of Microsoft's Visual Studio 2005 Team System (VSTS) is the most significant event in the software development lifecycle tools market for many years, and this book supplies the tools you need to take full advantage of it. Comprising three new role-based editions of Visual Studio, a server-side repository for all software...

Solaris and LDAP Naming Services: Deploying LDAP in the Enterprise
Solaris and LDAP Naming Services: Deploying LDAP in the Enterprise
This book is one of an on-going series of books collectively known as the Sun
BluePrints™ program. The Solaris™ and LDAP Naming Services BluePrint describes
best practices for planning and deploying naming services based on the Lightweight
Directory Access Protocol (LDAP). The introduction of native LDAP in the Solaris
...
Twitter Power 2.0: How to Dominate Your Market One Tweet at a Time
Twitter Power 2.0: How to Dominate Your Market One Tweet at a Time

Get the business leader's guide to using Twitter to gain competitive advantage.

Since 2006, forward-thinking companies like Apple, JetBlue, Whole Foods, and GM have discovered the instant benefits of leveraging the social media phenomenon known as Twitter to reach consumers directly, build their brand, and increase sales....

Astrophysical Lasers
Astrophysical Lasers
`A book of great educational value for graduate students and professional astronomers. ' Professor Dame Carole Jordan, University of Oxford

Progress in modern radio astronomy led to the discovery of space masers in the microwave range, and it became a powerful tool for studies of interstellar star-forming molecular
...
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