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Genetic Toxicology and Cancer Risk Assessment


Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation!

This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization.

Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines!

Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment

  • reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis
  • calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens
  • reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models
  • discusses the threshold concept of carcinogenesis
  • demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens
  • considers structural activity relationship (SAR) analysis of chemical carcinogenicity
  • describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays
  • illustrates the use of genetic biomarkers for dosimetry analysis
  • and more!
    Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.
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Python Game Programming by Example
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About This Book

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Intel Trusted Execution Technology for Server Platforms: A Guide to More Secure Datacenters (Expert's Voice in Security)
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John McAuley,EMC Corporation

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Industrial Strength Parallel Computing
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New Perspectives on Microsoft Office 2010, Second Course (Sam 2010 Compatible Products)
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The New Perspectives Series’ critical-thinking, problem-solving approach is the ideal way to prepare students to transcend point-and-click skills and take advantage of all that Microsoft Office 2010 has to offer. In developing the New Perspectives Series, our goal was to create books that give students the software concepts and...

Network Administration with FreeBSD
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Schaum's Outline of Electronic Communication
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If you want top grades and thorough understanding of electronic communications in less study time, this powerful study tool is the best tutor you can have! It takes you step-by-step through the subject and gives you accompanying problems with fully worked solutionsNplus hundreds of additional problems with answers at the end of chapters, so...

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