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Genome Instability in Cancer Development (Advances in Experimental Medicine and Biology)

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Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These important findings not only explain the occurrence of certain hereditary tumours, but they also set the stage for the development of anti-cancer drugs that specifically target activated oncogenes. However, in spite of tremendous progress towards the elucidation of key signalling pathways involved in carcinogenesis, most cancers continue to elude currently available therapies. This stands as a reminder that “cancer” is an extraordinarily complex disease: although some cancers of the haematopoietic system show only a limited number of characteristic chromosomal aberrations, most solid tumours display a myriad of genetic changes and considerable genetic heterogeneity. This is thought to reflect a trait commonly referred to as ‘genome instability’, so that no two cancers are ever likely to display the exact same genetic alterations. Numerical and structural chromosome aberrations were recognised as a hallmark of human tumours for more than a century. Yet, the causes and consequences of these aberrations still remain to be fully understood. In particular, the question of how genome instability impacts on the development of human cancers continues to evoke intense debate.

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Business Process Technology: A Unified View on Business Processes, Workflows and Enterprise Applications
Business Process Technology: A Unified View on Business Processes, Workflows and Enterprise Applications

In the last decade there has been an explosion of interest in the modeling and automation of business processes, and competence in this area is seen as increasingly critical to business competitiveness and stability. However, this has lead to a parallel explosion in solution approaches and technologies leading to a state-of-the-art that is...

Advanced Video Communications over Wireless Networks
Advanced Video Communications over Wireless Networks

Wireless video communications encompass a broad range of issues and opportunities that serve as the catalyst for technical innovations. To disseminate the most recent advances in this challenging yet exciting field, Advanced Video Communications over Wireless Networks provides an in-depth look at the fundamentals, recent technical...

FreeBSD Unleashed (With CD-ROM)
FreeBSD Unleashed (With CD-ROM)
Did you know that the special effects used in The Matrix were rendered using the FreeBSD system? Yahoo and the Internet Movie Database are also powered by FreeBSD. Now you can learn how to use FreeBSD to its full potential as well! FreeBSD Unleashed is a complete reference guide for FreeBSD administrators, developers, webmasters...

Information Systems: Achieving Success by Avoiding Failure
Information Systems: Achieving Success by Avoiding Failure
Despite people’s best efforts information systems are particularly prone to failure. Some systems never materialize, others appear late and/or over budget and those that are implemented often fail to deliver the promised levels of performance. The consequences of these failures affect people throughout the organization concerned and beyond,...
Reason 3 for Windows and Macintosh : Visual QuickStart Guide
Reason 3 for Windows and Macintosh : Visual QuickStart Guide
Combining pristine sound quality with a comfortably retro-styled virtual rack (including a polyphonic synthesizer, mixing console, sampler, and drum machine), Reason has won legions of fans since its introduction. Now, everyone is singing its praises -- from bands like Nine Inch Nails and Prodigy to video producers. Here to show you why is the...
Applied Algorithms: First International Conference, ICAA 2014, Kolkata, India, January 13-15, 2014. Proceedings (Lecture Notes in Computer Science)
Applied Algorithms: First International Conference, ICAA 2014, Kolkata, India, January 13-15, 2014. Proceedings (Lecture Notes in Computer Science)
This book constitutes the refereed proceedings of the First International Conference on Applied Algorithms, ICAA 2014, held in Kolkata, India, in January 2014. ICAA is a new conference series with a mission to provide a quality forum for researchers working in applied algorithms. Papers presenting original contributions related to the design,...
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