Since the first Handbook of Cell-Penetrating Peptides was prepared in 2001, the wealth of new information on the use of these peptides as transport systems has in fact served to confound the field. The constant internal change in the field of cell-penetrating peptides (CPPs) is due to recent research uncovering apparent ambiguities in cellular uptake. There is still neither a common terminology nor a uniform explanation for the penetrative mechanism of cell-penetrating peptides.
In this second edition of the Handbook of Cell-Penetrating Peptides, the authors summarize the current state of the field including recent reevaluations of earlier studies of CPP mechanisms. Beginning with an overview of the classes of peptides and their individual uptake mechanisms, from the earlier lipid models to the more recent endocytotic pathways, the book demonstrates the diversity and the opportunity for these biologically active proteins to serve as future drug leads. The text then covers the use of CPPs in gene modulation, addressing the application of antisense and decoy oligonucleotides, as well as the new avenue of research targeting specific tumors and other tissues-questions that had barely been asked when the first edition was published.
By summarizing the diffuse information regarding CPPs, including the ambiguities and variety of mechanisms, the Handbook of Cell-Penetrating Peptides provides the most solid foundation available from which to expand the potential of this rapidly growing field of medicine.
Atypical Parkinsonian Disorders: Clinical and Research Aspects (Current Clinical Neurology)
A comprehensive review of what is known not only about the cause and treatment of atypical parksonian disorders, but also the issues that clinicians, researchers, patients, and caregivers face in dealing with them. The authors cover the basic science (history, epidemiology, genetics, pathology, nosology, computer modeling, and animal models),...
One of the first books on Autodesk's new Mudbox 3D modeling and sculpting tool!
Autodesk's Mudbox was used to create photorealistic creatures for The Dark Knight, The Mist, and others films. Now you can join the crowd interested in learning this exciting new digital modeling and sculpting tool with this...
SOA Patterns with BizTalk Server 2009
SOA is about architecture, not products and SOA enables you to create better business processes faster than ever. While BizTalk Server 2009 is a powerful tool, by itself it cannot deliver long-lasting, agile solutions unless we actively apply tried and tested service-oriented principles.
The current BizTalk Server books are all for the...
Mathematical and Computational Modeling of Tonality: Theory and Applications
From the Preface:
Blending ideas from operations research, music psychology, music theory, and cognitive science, this book aims to tell a coherent story of how tonality pervades our experience, and hence our models, of music.
The story is told through the developmental stages of the Spiral Array model for tonality, a...