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Herpes zoster is a serious neurocutaneous disease which has been underestimated
in terms of its burden, particularly in the elderly population. The
overall incidence of herpes zoster in Europe is about 3 per 1,000 people and
more than 10 per 1,000 people per year aged more than 80 years. Due to the
growing life expectancy of the Central European population, the incidence of
herpes zoster and its burden is very likely to increase further in the near future.
The onset of herpes zoster is almost always associated with waning
varicella–zoster virus (VZV) specific cellular immunity. Herpes zoster is characterised
by a more or less painful vesicular rash usually restricted to a defined area
of the skin (dermatoma), which is innervated by the branches of a single sensory or
a cranial nerve. The most common debilitating complication of herpes zoster is
postherpetic neuralgia, which is especially seen in patients beyond 50 years of age. |
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