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Hughes Syndrome: Antiphospholipid Syndrome

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The studies and discussions presented in the second edition of the Hughes Syndrome text had their beginning with a 1983 British Medical Journal publication entitled “Thrombosis, abortion, cerebral disease and the lupus anticoagulant.” In the mid-20th-century, it was recognized that some patients with systemic lupus erythematosus had biological false positive serological tests for syphilis, often coincident with the presence of an anticoagulant in plasma and the some of these patients (particularly ones with somewhat atypical of patterns of lupus) paradoxically manifested an increased incidence of procoagulant complications. Nothing much was made of these associations, however, until Graham Hughes, author of the above citation, applied his talents of astute bedside observation, knowledge of disease mechanisms, imagination, and a “bloodhound” instinct for following relevant clues. Graham and his colleagues early-on documented vasculopathy as basis for the diffuse (variable) pathology characteristic of the syndrome; evidence that procoagulant features were mediated by antiphospholipid autoantibodies (aPL) followed. Over the past two decades, investigators around the world have turned their attention to the study of the Hughes syndrome. (Contributors to this text include 83 clinicians and/or scientists from 13 countries in Europe, the Americas, Near East, and Asia. They represent more than a dozen clinical subspecialties and several basic science disciplines; professionals and students in these fields will need access to this book, whether in institutional libraries or personal collections – good news for the publisher.)
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