Home | Amazing | Today | Tags | Publishers | Years | Account | Search 
Iminosugars: From Synthesis to Therapeutic Applications

Buy
The field of iminosugars is a very exciting area of research. These carbohydrate mimetics were first imagined and synthesized by chemists in the 1960s before being isolated from Nature a few years later. Since the discovery of their biological activity as potent glycosidase inhibitors in the 1970s, iminosugars have been the subject of intense studies at the interface between organic synthesis, glycobiology and medicinal science. In 1999, Arnold Stütz edited the first book devoted to iminosugars (Iminosugars as Glycosidase Inhibitors: Nojirimycin and Beyond, Wiley-VCH, New York; 1999). The title of this outstanding monograph reflected the main features of the field at that time and the strong interplay between isolation of natural products such as nojirimycin, synthesis and biochemical research. However, the most striking word of the title is undoubtedly the preposition ‘beyond’ which was premonitory. The pace of discovery in the area of iminosugars has indeed increased spectacularly over the past decade. The scope of their biological activity has been extended to the inhibition of numerous proteins including enzymes acting on sugars (glycosyltransferases, glycogen phosphorylases, nucleoside-processing enzymes, UDP-Galp mutase) but also metalloproteinases. GlysetTM and ZavescaTM, the two first examples of iminosugar-based drugs, have been commercialized for complications associated with diabetes and for the treatment of Gaucher’s disease, respectively. New biological and medicinal applications are being uncovered almost every month!

Iminosugars form undoubtedly the most attractive of carbohydrate mimics reported so far. In these structures, the substitution of the endocyclic oxygen of sugars by a basic nitrogen atom leads to remarkable biological properties and raises many challenges in organic synthesis. Since the discovery of their biological activity as glycosidase inhibitors in the 1970’s, these polyvalent molecules have progressively made their way from the laboratory to the clinic.

The impressive series of discoveries in the field over the past ten years indicates clearly that it is “a boom time” for iminosugar chemistry and biology. The scope of their profile as inhibitors has been extended to a number of enzymes such as phosphorylases, glycosyltransferases or metalloproteinases, and iminosugars now constitute lead compounds for the development of new therapeutic agents for a wide range of diseases including diabetes, viral infections, lysosomal storage disorders and tumor metastasis.

Latest developments, from iminosugar synthesis to their use in clinical studies, are presented in this book, which contains contributions from over fifteen of the major chemists, biochemists and drug developers in this rapidly expanding field. An extensive table correlating the structures of more than 600 iminosugars of therapeutic interest with their biological activities is also included in the book and should prove particularly useful to aid with the design and the discovery of novel bioactive substances.

Iminosugars: From Synthesis to Therapeutic Application provides a unique resource for academic and industrial researchers working in the field of iminosugars and glycomimetics of biological and/or therapeutic interest: organic chemists, medicinal chemists, carbohydrate chemists and medical scientists.

(HTML tags aren't allowed.)

Boost.Asio C++ Network Programming Cookbook
Boost.Asio C++ Network Programming Cookbook

Key Features

  • Build highly efficient distributed applications with ease
  • Enhance your cross-platform network programming skills with one of the most reputable C++ libraries
  • Find solutions to real-world problems related to network programming with ready-to-use recipes using this...
eBay Photos That Sell: Taking Great Product Shots for eBay and Beyond
eBay Photos That Sell: Taking Great Product Shots for eBay and Beyond
"I've been an admirer of Dan Gookin since he wrote DOS For Dummies and spawned the For Dummies phenomenon. He takes things to a new level with this amazing and much needed book on practical product photography. Use his advice and you'll simply make more money. Highly recommended."
—John C.
...
Dns in Action: A Detailed And Practical Guide to Dns Implementation, Configuration, And Administration
Dns in Action: A Detailed And Practical Guide to Dns Implementation, Configuration, And Administration
Recently, while driving to my work, I listened to radio as usual. Because of the establishment of the new EU (European Union) domain, there was an interview with a representative of one of the Internet Service Providers. For some time the interview went on, boringly similar to other common radio interviews, but suddenly the presswoman started to...

Cocoon Developer's Handbook (Developer's Library)
Cocoon Developer's Handbook (Developer's Library)
Cocoon is one of the showpieces of the Apache XML project. It is a powerful framework that allows developers to more efficiently set up, create, and maintain sophisticated Web-oriented applications. It has attracted widespread attention because it solves a substantial problem for Web developers. Yet Cocoon's reliance on a wide array of open source...
Microsoft Expression Web 4 In Depth
Microsoft Expression Web 4 In Depth

Expression Web is a powerful web development product, and there are plenty of books about it. That puts readers in a tight spot when trying to figure out which book to purchase to learn how to use Expression Web to its fullest. I’ve read a lot of technical books in my career, and the ones I value the most are the ones that I keep going...

Clinical Textbook of Addictive Disorders, Third Edition
Clinical Textbook of Addictive Disorders, Third Edition

This authoritative work comprehensively examines all aspects of addictive disorders and their treatment. Leading researchers and practitioners identify best practices in assessment and diagnosis and provide tools for working with users of specific substances. Issues in working...

©2019 LearnIT (support@pdfchm.net) - Privacy Policy