Home | Amazing | Today | Tags | Publishers | Years | Account | Search 
Immunopharmacology of Platelets (Handbook of Immunopharmacology)

Buy
Although anucleated, blood platelets are extraordinarily efficient cells and still the subject of fruitful investigations in haematology, in vascular physiology, in biochemistry, and more recently in immunology and in physiopathology where their metabolism has been implicated as a source of potential effector compounds. It is challenging for cell physiologists that these blood elements reset so strongly to environmental stimuli, expressing a tremendous and rapid modification of their shape and metabolism, with only their intrinsic and relatively locked properties and without the active machinery of the nucleus. Platelet literature already covers yards of shelves in haematology departments, in blood centre libraries and in atherosclerosis research laboratories. Why produce a new book in such a well-explored area? It is to the credit of Dr Clive Page, the series editor of The Handbook of Immunopharma~ology, that he has focused thought over the last decade, by his own investigations and by a careful survey of the literature, on the involvement of blood platelets outside their classical field of application, and more precisely in physiopathological mechanisms of allergy and inflammation. We have logically let him present an introductory chapter, which summarizes, with great precision what will be found in more detail in the other contributions to this work.

Dr Boris Vargaftig, at the Institute Pasteur in Paris, has contributed largely to the development of animal models in allergic and inflammatory disorders, and is particularly well qualified to present here, with the collaboration of Dr Anthony Coyle, a review of such models for investigating the potential implications of platelets in these pathologies. The results they, and others, have obtained with animal substitutes have thrown some light on a possible place for platelets in the cell network of acute inflammation or allergic reactions, and more particularly, asthma. As already stressed above, another fascinating aspect of platelets is the absence of a nucleus, which strengthens the importance of the membrane and receptors in the physiological mechanisms of thrombocyte activation, together with the understanding of the intracellular signalling pathways sustaining their haematological functions. The rapidly moving knowledge in this domain has been carefully covered by the specialists in the matter, Dr Michael Kroll and Dr Andrew Schafer in Houston. Although specifically centred on biochemical mechanisms leading to aggregation, their extensive analysis brings interesting perspectives to the potential participation of platelets in immunological and physiopathological processes. Their contribution is perfectly complemented by that of Dr John McGregor, in Lyon, which has taken into account the active role played by adhesion molecules and membrane-bound ligands in mediating the platelet involvement in inflammation.
(HTML tags aren't allowed.)

Solar Rooftop DIY: The Homeowner's Guide to Installing Your Own Photovoltaic Energy System (Countryman Know How)
Solar Rooftop DIY: The Homeowner's Guide to Installing Your Own Photovoltaic Energy System (Countryman Know How)

The do-it-yourself guide for converting your home to solar power

Solar energy is clean, efficient, sustainable―and expensive. Or is it? Many homeowners simply assume that the cost of solar panels is out of their reach, but in reality, the technology is quickly becoming attainable for the middle class. Rather...

Programming for TV, Radio & The Internet, Second Edition: Strategy, Development & Evaluation
Programming for TV, Radio & The Internet, Second Edition: Strategy, Development & Evaluation

Where do program ideas come from? How are concepts developed into saleable productions? Who do you talk to about getting a show produced? How do you schedule shows on the lineup? What do you do if a series is in trouble? The answers to these questions, and many more, can be found in this comprehensive, in-depth look at the roles and...

Programming in Prolog: Using the ISO Standard
Programming in Prolog: Using the ISO Standard

Originally published in 1981, this was the first textbook on programming in the Prolog language and is still the definitive introductory text on Prolog. Though many Prolog textbooks have been published since, this one has withstood the test of time because of its comprehensiveness, tutorial approach, and emphasis on general programming...


The IMS : IP Multimedia Concepts and Services in  the Mobile Domain
The IMS : IP Multimedia Concepts and Services in the Mobile Domain
We have telephony to talk to each other, messaging to dispatch mail or instant messages, browsing to read published content and search engines to locate content sites. However, current mobile networks do not provide the possibility for one application rich terminal to communicate with another in a peer-to-peer session beyond voice calls. Mobile...
Troubleshooting Remote Access Networks (CCIE Professional Development)
Troubleshooting Remote Access Networks (CCIE Professional Development)
A guide to understanding the troubleshooting tools, commands, and methodologies that enable reliable performance for remote access services

* Gain a solid grasp of enterprise telecommunications technology fundamentals, including service options and clocking, line coding, and framing in carrier systems
* Understand how network traffic
...

Autodesk Revit Architecture 2011: No Experience Required
Autodesk Revit Architecture 2011: No Experience Required

Learn Revit Architecture step by step with this project-based tutorial

Revit Architecture is the leading Building Information Modeling (BIM) software for architects and others in related fields. Written by renowned Revit trainer Eric Wing, this simple, yet engaging tutorial teaches you the program's basics.

...

©2019 LearnIT (support@pdfchm.net) - Privacy Policy