Marine organisms produce a wide array of toxins, many of which are not only structurally unusual, but also show potent and interesting modes of action. Since the discovery of tetrodotoxin, a pufferfish toxin, as a potent and selective blocker of Na+ channels in 1964, it has been widely used as a research tool in pharmacological and physiological research. This has led to the identification of a number of important biological functions for Na+ channels. In recent years, much biological research has been carried out at molecular and cellular levels, and therefore selective inhibitors of enzymes and selective antagonist/agonists of receptors and channels have become increasingly important research tools. Accordingly, interest in using such compounds as reagents has increased. Marine toxins are some of the most popular research tools and have already contributed much to our understanding of biological processes and disease mechanisms.
Models and Analysis for Distributed Systems (ISTE)
Verification and hence modeling are a mandatory but intricate problem for engineers
developing embedded distributed real-time systems that are entrusted with critical
safety applications like medical care, transportation, energy production, industrial
processes, military operations. Therefore, while emerging 40 years ago, first for... Business Intelligence in the Digital Economy: Opportunities, Limitations and Risks Business Intelligence in the Digital Economy: Opportunities, Limitations and Risks describes what Business Intelligence (BI) is, how it is being conducted and managed and its major opportunities, limitations, issues and risks. This book takes an in-depth look at the scope of global technological change and BI. During this transition to BI,...
Encyclopedia of Virtual Communities and Technologies Advances in computer and telecommunications technologies during the past several decades, have facilitated the creation of virtual communities and organizations throughout the world. As the growth in virtual communities accelerates, researchers are facing new challenges to learn about the latest of research and practices in this fast growing filed.... Now You See It, Now You Don't!: Lessons in Sleight of Hand
A new and simple learn-by-picture method that makes it easy for anyone aged twelve and up to perform all the classic sleights just as they are done by the world's greatest professional magicians. Long-time magician Bill Tarr has teamed up with Barry Ross, an illustrator famous for his instructional sports diagrams, for easy-to-follow,...