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Molecular Diagnosis of Cancer: Methods and Protocols (Methods in Molecular Medicine)

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We are currently experiencing a fundamental shift in the way in which we approach the characterization of cancer. Never before has the make up of cancer tissues and individual cells been so exhaustively researched and char- terized. We are now capable of producing molecular “fingerprints” that ch- acterize the expression of all known and unknown genes within tumors and their surrounding tissues. More than 30,000 different genes may be measured in each patient’s tumor in a single experiment. Simultaneously, novel therapies that exploit the molecular roadmap have been developed and are now being offered to patients. These novel agents, such as Glivec, Herceptin, Iressa, and others, specifically target individual genes within tumors and can produce d- matic responses in some patients. These drugs are only the forerunners of a coming tidal wave of novel therapeutics that individually target specific m- ecules within cancer cells―more than 300 such agents are currently in phase I or II clinical trials. This is an exciting time for cancer specialists and patients alike. However, if we have learned anything from the past 50 or more years of research into cancer, it is that Lord Beaverbrook, in founding the British national health service in the 1950s, was frighteningly prescient when he defined the primary goal of health care to be “Diagnosis, Diagnosis, Diag- sis. ” Now, more than ever, it is essential that appropriate diagnostic methods and approaches are applied to the selection of patients for treatment.

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Structural Complexity Management: An Approach for the Field of Product Design
Structural Complexity Management: An Approach for the Field of Product Design

Product design is characterized by a steady increase in complexity. The main focus of this book is a structural approach on complexity management. This means, system structures are considered in order to address the challenge of complexity in all aspects of product design. Structures arise from the complex dependencies of system elements....

Digital Photography in Available Light: Essential Skills, Third Edition (Photography Essential Skills)
Digital Photography in Available Light: Essential Skills, Third Edition (Photography Essential Skills)
This comprehensive guide teaches all the digital skills the amateur or student photographer will need when photographing on location, written in a practical no nonsense and entertaining style

Digital Photography in Available Light is an inspirational guide as well as a structured learning tool for mastering the essential
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The Rough Guide to Yosemite 3 (Rough Guide Travel Guides)
The Rough Guide to Yosemite 3 (Rough Guide Travel Guides)

Make the most of your time with The Rough Guide to Yosemite, the ultimate guide

to California’s most stunning park. The full-colour section introduces Yosemite’s highlights, from hiking the Mist Trail and rock-climbing in the Valley to insight into the...


Saints of Ninth- and Tenth-Century Greece (Dumbarton Oaks Medieval Library)
Saints of Ninth- and Tenth-Century Greece (Dumbarton Oaks Medieval Library)

Saints of Ninth- and Tenth-Century Greece collects funeral orations, encomia, and narrative hagiography. Together, these works illuminate one of the most obscure periods of Greek history?when holy men played central roles as the Byzantine administration reimposed control on southern and central Greece in the wake of Avar,...

Wireless Operational Security
Wireless Operational Security

Wireless Operational Security addresses the operational and day-to-day security management requirements of 21st Century companies. Wireless networks can easily be reconfigured, are very mobile, allow for potentially nonstop exposure, and require the level of security be scrutinized even more than for wired networks. This includes...

MCSD Visual Basic 6 Exams : Exams 70-175 and 70-176 Training Guide
MCSD Visual Basic 6 Exams : Exams 70-175 and 70-176 Training Guide
Each Training Guide will be organized around the exam objectives. This makes it very easy for readers to focus on areas where they need to improve. It also helps them identify what the key topics on the exam will be.

MCSD Training Guide: Visual Basic 6 Exams is
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