Molecular Imaging: An Essential Tool in Preclinical Research, Diagnostic Imaging, and Therapy (Ernst Schering Foundation Symposium Proceedings)

Molecular Imaging: An Essential Tool in Preclinical Research, Diagnostic Imaging, and Therapy (Ernst Schering Foundation Symposium Proceedings), 9783540210214 (3540210210), Springer, 2004

"Molecular imaging" has been previously defined as "the in vivo characterization and measurement of biologic processes at the cellu lar and molecular level." This broad definition emerged during the last few years as a consequence of the convergence of molecular and cell biology with imaging science, including medical physics and technology. One of the major goals of molecular imaging has be come the development of noninvasive strategies of "molecular profil ing" in living subjects, i.e., the acquisition and analysis of maps re flecting the spatial and temporal distribution of a given molecular target at a precise anatomical location without biopsies. The map ping of disease-relevant gene expression profiles in vivo would be especially important for individualizing established therapy regimens in clinical practice and selecting patients for novel experimental therapies.

The continuous progress in the understanding of molecular processes of disease formation and progression attributes an increasing importance to biomedical molecular imaging methods. The purpose of this workshop was to discuss and overview multiple applications and emerging technologies in the area of diagnostic imaging including its fundamental capabilities in preclinical research, the opportunities for medical care, and the options involving therapeutic concepts. The book provides the reader with state-of-the-art information on the different aspects of diagnostic imaging, illuminating new developments in molecular biology, imaging agents and molecular probe design, and therapeutic techniques.

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