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Molecular Neurosurgery with Targeted Toxins

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Pioneers and leading researchers explain the theory and techniques of using targeted toxins experimentally. The highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals is treated in detail to give a potential user the knowledge to comfortably use the techniques involved. The uses of important new lesioning agents such as anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of CNS demyelination are explained by experts in the field.

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The Six Sigma Handbook: The Complete Guide for Greenbelts, Blackbelts, and Managers at All Levels, Revised and Expanded Edition
The Six Sigma Handbook: The Complete Guide for Greenbelts, Blackbelts, and Managers at All Levels, Revised and Expanded Edition

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The C++ Programming Language (hardcover) (4th Edition)

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Integrating and Extending BIRT (2nd Edition)
The world-wide developer community has downloaded over three million copies of BIRT (Business Intelligence and Reporting Tools) from the Eclipse web site. Built on the open-source Eclipse platform, BIRT is a powerful reporting system that provides an end-to-end solution, from creating and deploying reports to integrating report capabilities in...

Securing the Perimeter: Deploying Identity and Access Management with Free Open Source Software
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Leverage existing free open source software to build an identity and access management (IAM) platform that can serve your organization for the long term. With the emergence of open standards and open source software, it’s now easier than ever to build and operate your own IAM stack.

The most common culprit of...

Seasonal Patterns of Stress, Immune Function, and Disease
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Most animals exhibit seasonal variation in their reproduction and survival simply because most of them live in environments in which food availability varies seasonally. This is true in the tropics as well as at the higher latitudes, but at the higher latitudes the combined challenge of food shortage and low temperature makes...
PHP Functions Essential Reference
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PHP Functions Essential Reference is a detailed and practical function reference for the PHP programming language. Concise and authoritative, this working programmer's guide covers the core function groups plus 300 additional commonly used PHP functions, and details 800 more functions on the...

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