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Natural Products: Drug Discovery and Therapeutic Medicine

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A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.

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Ocular Trauma: Principles and Practice
Ocular Trauma: Principles and Practice

Ocular Trauma: Principles and Practice is the first comprehensive clinical
reference on ocular injuries in more than a decade. Each chapter gives you
detailed instructions on evaluation, treatment, and management, including "what
to do", "how to do it", and "why to do it."
...

Interferon Methods and Protocols (Methods in Molecular Medicine)
Interferon Methods and Protocols (Methods in Molecular Medicine)

A compendium of optimized methods to measure type I interferon efficacy as an antiproliferative or an antiviral agent. These cutting-edge techniques range from the simple to the highly complex and serve to illuminate the signaling cascades and the activation of enzymatic pathways prompted by interferon. The protocols follow the successful...

Clinical Applications of PCR (Methods in Molecular Biology)
Clinical Applications of PCR (Methods in Molecular Biology)

In this updated second edition, leading researchers apply molecular diagnostics to the many recent advances that have occurred in polymerase chain reaction( PCR)-based technologies. Highlights include real-time PCR, which allows the technique to be performed in a quantitative manner with improved sensitivity, robustness, and resilience to...


Immunochemical Protocols (Methods in Molecular Biology)
Immunochemical Protocols (Methods in Molecular Biology)

Immunochemical techniques have been in use for many years with early examples of bacterial strain typing dating back to the 1940s. The basis for the science is the exquisite elegance of the mammalian immune system with its ability to recognize foreign proteins and to manufacture antibody m- ecules that strongly bind to the substances that...

Principles of Molecular Cardiology (Contemporary Cardiology)
Principles of Molecular Cardiology (Contemporary Cardiology)

An easy-to-read survey of all the latest developments in molecular cardiologic research and therapy. The authors explain in a readable style the complex process of the heart's development, the molecular basis of cardiovascular diseases, and the translation of these research advances to actual clinical treatments. The expert information...

Angiogenesis and Direct Myocardial Revascularization (Contemporary Cardiology)
Angiogenesis and Direct Myocardial Revascularization (Contemporary Cardiology)

An interdisciplinary panel of pioneers and opinion leaders review the basic, preclinical, clinical, and developmental pathways to new treatment strategies, such as therapeutic angiogenesis and myogenesis. The authors take advantage of new biological understanding, novel therapeutic targets, multiple available and well-studied therapeutic...

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