A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
Invariant Algebras And Geometric Reasoning The demand for more reliable geometric computing in robotics, computer vision and graphics has revitalized many venerable algebraic subjects in mathematics among them, Grassmann Cayley algebra and Geometric Algebra. Nowadays, they are used as powerful languages for projective, Euclidean and other classical geometries.
This book contains the...
Epilepsy and Your Child: The 'At Your Fingertips' Guide (Class Health)
Epilepsy is no respecter of age. It most commonly presents
in childhood and tends to be seen at its most severe during the
childhood years. It remains a uniquely frightening, stigmatising
and misunderstood disorder. For all these reasons, the impact of
epilepsy in a child on all the family members can be enormous.
Vascular Surgery (Springer Specialist Surgery Series)
This book provides coverage of a broad range of topics in the field of vascular surgery to
residents, registrars in training, and to recent graduates of training programs. The book
is meant to be a practical rendition of the basic knowledge and clinical management
required for optimal care of vascular surgical patients. Each chapter...
Thieme Clinical Companions: Ultrasound
Everything you need to know, see, and interpret in your daily work, presented in words and pictures!
Basic physical and technical principles, examination techniques, and documentation are covered in the gray part of the book.
What differential diagnoses should you consider for specific signs and symptoms? When can...
Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volume 2
Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volumes 1 and 2, present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer. These comprehensive volumes integrate the...
Mitochondria: Practical Protocols (Methods in Molecular Biology)
This book offers a broad collection of methods for studying the molecular biology, function, and features of mitochondria. In the past decade, mitochondrial research has elucidated the important influence of mitochondrial processes on integral cell processes. This practical guide presents a wide spectrum of mitochondrial methods, each written...