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Several years ago, when the discovery of catalytic RNA was recognized in a public manner, many people asked if new ?elds of therapy would soon be available. Although some tentative positive answers were given, nobody would say with certainty that RNA of various kinds was a truly promising means of altering gene expression. In fact, over the past decade, both our knowledge of RNAs with different functions and the utility of RNA in the inhibition or enhancement of gene expression have occurred with great drama. We proceeded in terms of possible therapeutic tools from RNase P and group I introns through "hammerhead" RNA enzymes, antisense technology, and more recently, to RNAi and its derivatives. A useful practical method of RNA delivery in animals will complete the picture. The diversity of RNA and the varied role of it inside cells and in therapy should be a tremendous challenge for young molecular biologists. This volume will make their task easier. Sidney Altman Sterling Professor of Molecular, Cellular & Devel- mental Biology, Nobel Laureate Department of Molecular, Cellular and Developm- tal Biology Yale University V NGTPR 4/23/05 1:00 PM Page VI VI Foreword Delivery of nucleic acids to cells in an animal remains a challenging problem. It is the major obstacle to success of therapeutic approaches using genes and oli- nucleotides, including siRNAs. Solutions found so far by chemists are satisfactory only for transfection of cells in culture. |
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Adobe Photoshop Lightroom and Photoshop Workflow Bible
The digital photographer's workflow is divided into two distinct parts - the Production Workflow and the Creative Workflow. The Production workflow is used to import and organize large numbers of images, and prepare them for presentation via proof printing, Web, or slideshow. Increasingly, photographers are turning to Adobe's... | | Agent-Based Modeling and Simulation with Swarm
Swarm-based multi-agent simulation leads to better modeling of tasks in biology, engineering, economics, art, and many other areas. It also facilitates an understanding of complicated phenomena that cannot be solved analytically. Agent-Based Modeling and Simulation with Swarm provides the methodology for a multi-agent-based... | | Schaum's Outline of Data Structures with Java, Second EditionLike other Schaum’s Outlines, this book is intended to be used primarily for self study. It is suitable as a study guide in a course on data structures using the Java programming language. In American universities, this is typically the second course in the computer science major. The book is also serves well as a reference on data structures... |
Sacroiliac Joint Disorder: Accurately Diagnosing Low Back Pain
This book focuses on low back pain, comprehensively covering the concept, etiology, diagnosis and treatment for those types of pain specifically caused by sacroiliac joint dysfunction. Particular attention is given to understanding the pathology, diagnostic techniques and useful methods for successfully treating patients. Sacroiliac joint pain,... | | | | |
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