Home | Amazing | Today | Tags | Publishers | Years | Account | Search 
Protein Tyrosine Kinases: From Inhibitors to Useful Drugs (Cancer Drug Discovery and Development)

Buy

Leading researchers, from the Novartis group that pioneered Gleevec/Glivec™ and around the world, comprehensively survey the state of the art in the drug discovery processes (bio- and chemoinformatics, structural biology, profiling, generation of resistance, etc.) aimed at generating PTK inhibitors for the treatment of various diseases, including cancer. Highlights include a discussion of the rationale and the progress made towards generating "selective" low molecular-weight kinase inhibitors; an analysis of the normal function, role in disease, and application of platelet-derived growth factor antagonists; and a summary of the factors involved in successful structure-based drug design. Additional chapters address the advantages and disadvantages of in vivo preclinical models for testing protein kinase inhibitors with antitumor activity and the utility of different methods in the drug discovery and development process for determining "on-target" vs "off-target" effects of kinase inhibitors.

(HTML tags aren't allowed.)

A Primer on Scientific Programming with Python (Texts in Computational Science and Engineering)
A Primer on Scientific Programming with Python (Texts in Computational Science and Engineering)

The book serves as a first introduction to computer programming of scientific applications, using the high-level Python language. The exposition is example and problem-oriented, where the applications are taken from mathematics, numerical calculus, statistics, physics, biology and finance. The book teaches "Matlab-style" and...

Ultra Wideband Systems: Technologies and Applications (Communications Engineering)
Ultra Wideband Systems: Technologies and Applications (Communications Engineering)
Ultra wideband technology turns the radio spectrum available to wireless applications from a country road into a high-speed ten lane super freeway, and the destination is the future of wireless technology. UWB is a huge leap forward because it offers wide bandwidth with little interference, allowing multiple UWB signals to share a single channel....
Managing Trust in Cyberspace
Managing Trust in Cyberspace

In distributed, open systems like cyberspace, where the behavior of autonomous agents is uncertain and can affect other agents' welfare, trust management is used to allow agents to determine what to expect about the behavior of other agents. The role of trust management is to maximize trust between the parties and thereby provide a basis...


Nested Relations and Complex Objects in Databases (Lecture Notes in Computer Science)
Nested Relations and Complex Objects in Databases (Lecture Notes in Computer Science)

This volume was primarily intended to present selected papers from the workshop on Theory and Applications of Nested Relations and Complex Objects, held in Darmstadt, FRG, from April 6-8, 1987. Other papers were solicited in order to provide a picture of the field as general as possible. Research on nested relations and complex objects...

MCSA/MCSE 70-299 Exam Cram 2 : Implementing and Administering Security in a Windows 2003 Network
MCSA/MCSE 70-299 Exam Cram 2 : Implementing and Administering Security in a Windows 2003 Network
The 70-299 exam measures your ability to implement, manage, maintain, and troubleshoot security in a Windows Server 2003 network infrastructure and also plan and configure a Windows Server 2003 PKI. The MCSE 70-299 Exam Cram 2 gives you the essential information you need to know to learn how to implement, manage,...
Fundamentals of Electric Circuits
Fundamentals of Electric Circuits

You may be wondering why we chose a photo of astronauts working in space on the Space Station for the cover. We actually chose it for several reasons. Obviously, it is very exciting; in fact, space represents the most exciting frontier for the entire world! In addition, much of the station itself consists of all kinds of circuits! One...

©2021 LearnIT (support@pdfchm.net) - Privacy Policy