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Protein Tyrosine Kinases: From Inhibitors to Useful Drugs (Cancer Drug Discovery and Development)

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Leading researchers, from the Novartis group that pioneered Gleevec/Glivec™ and around the world, comprehensively survey the state of the art in the drug discovery processes (bio- and chemoinformatics, structural biology, profiling, generation of resistance, etc.) aimed at generating PTK inhibitors for the treatment of various diseases, including cancer. Highlights include a discussion of the rationale and the progress made towards generating "selective" low molecular-weight kinase inhibitors; an analysis of the normal function, role in disease, and application of platelet-derived growth factor antagonists; and a summary of the factors involved in successful structure-based drug design. Additional chapters address the advantages and disadvantages of in vivo preclinical models for testing protein kinase inhibitors with antitumor activity and the utility of different methods in the drug discovery and development process for determining "on-target" vs "off-target" effects of kinase inhibitors.

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Penetration Testing: A Hands-On Introduction to Hacking
Penetration Testing: A Hands-On Introduction to Hacking

Penetration testers simulate cyber attacks to find security weaknesses in networks, operating systems, and applications. Information security experts worldwide use penetration techniques to evaluate enterprise defenses.

In Penetration Testing, security expert, researcher, and trainer Georgia Weidman
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Beginning Ruby on Rails E-Commerce: From Novice to Professional
Beginning Ruby on Rails E-Commerce: From Novice to Professional

Beginning Ruby on Rails E-Commerce: From Novice to Professional is the first book of its kind to guide you through producing e-commerce applications with Railsthe stacked web framework taking the world by storm. The book dives right into the process of creating a production-level web application using agile methodologies and test-driven...

User Experience Re-Mastered: Your Guide to Getting the Right Design
User Experience Re-Mastered: Your Guide to Getting the Right Design

Good user interface design isn't just about aesthetics or using the latest technology. Designers also need to ensure their product is offering an optimal user experience. This requires user needs analysis, usability testing, persona creation, prototyping, design sketching, and evaluation through-out the design and development process.
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VMware ESX Server: Advanced Technical Design Guide (Advanced Technical Design Guide series)
VMware ESX Server: Advanced Technical Design Guide (Advanced Technical Design Guide series)
Detailing the design and deployment of a VMware ESX Server environment, and written from the practical experience of proven VMware engineers, this book provides IT architects with the insight needed to tackle tough design issues such as ESX Server security, network and SAN design, host hardware selection, guest selection and configuration,...
Intelligent Automation and Systems Engineering (Lecture Notes in Electrical Engineering)
Intelligent Automation and Systems Engineering (Lecture Notes in Electrical Engineering)

Intelligent systems are required to facilitate the use of information provided by the internet and other computer based technologies. This book describes the state-of-the-art in Intelligent Automation and Systems Engineering. Topics covered include Intelligent decision making, Automation, Robotics, Expert systems, Fuzzy systems,...

Android Recipes: A Problem-Solution Approach
Android Recipes: A Problem-Solution Approach

Android continues to be one of the leading mobile OS and development platforms driving today's mobile innovations and the apps ecosystem. Android appears complex, but offers a variety of organized development kits to those coming into Android with differing programming language skill sets.

Android Recipes: A...

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