Home | Amazing | Today | Tags | Publishers | Years | Account | Search 
Regulatory Mechanisms of Striated Muscle Contraction (Advances in Experimental Medicine and Biology)

Buy
The discovery of troponin by Professor Setsuro Ebashi opened a new era for research into the regulation of striated muscle contraction. This volume is the proceedings of the symposium held at Okazaki, Japan, in 2005 celebrating the 40th anniversary of that discovery.

Professor Ebashi started his work on muscle contraction when he was a young researcher, immediately after World War II, having been inspired by the book Chemistry of Muscular Contraction by Albert Szent-Györgyi. He was fascinated by the dynamic features of the contractile processes performed by the two contractile proteins, myosin and actin, in the presence of ATP. However, he wondered about the mechanism by which muscle relaxes after contraction. He proceeded with biochemical studies of muscle relaxation and found in 1952 that a factor present in the supernatant of the suspension of minced frog skeletal muscle caused relaxation of glycerinated muscle fibers. Based on this finding and succeeding work, he came to the conclusion that the relaxation of contracted muscle was caused by the uptake of calcium ions from the cytosol into the relaxing factor (sarcoplasmic reticulum). His work greatly contributed to elucidating the entire processes of excitation–contraction coupling, particularly the role of calcium ions in triggering the contractile response of myofibrils.

Then he found that superprecipitation of actomyosin, i.e., an in vitro contraction model, became sensitive to calcium ion concentration in the presence of a protein factor other than myosin and actin. This factor showed some similarity to tropomyosin, which had been reported by Bailey, and thus was called native tropomyosin.

When I started working in Professor Ebashi’s laboratory in 1963 as a graduate student, he was working very hard with his wife to characterize the biochemical properties of native tropomyosin. Tropomyosin, reported by Bailey, was actually isolated by isoelectric precipitation from native tropomyosin, but it did not confer any calcium sensitivity to actomyosin. In 1965, Professor Ebashi succeeded in isolating a new protein named “troponin” from native tropomyosin, which, in association with tropomyosin, made actomyosin sensitive to calcium ions. With a series of studies in the 1960s, the molecular basis for the regulation of muscle contraction was established. Since that time, troponin has been the central object in research on the regulation of striated muscle contraction. Properties of troponin, which consists of three different components, have been extensively investigated as revealing insights into a representative calcium-receptive and calcium-regulatory protein.

Professor Ebashi and I sincerely hoped that this volume would become a milestone for future developments in the study of the regulation of muscle contraction and related biomedical sciences. I would like to express my profound gratitude to all contributors for their heartfelt cooperation.
(HTML tags aren't allowed.)

CSS Hacks and Filters: Making Cascading Stylesheets Work
CSS Hacks and Filters: Making Cascading Stylesheets Work
Here's how to make CSS work the way it should

Cascading Style Sheets, the technology meant to bring order out of chaos by letting you update Web sites effortlessly, just doesn't always work. You recognize that when you discover your graphics, perfectly positioned in Firefox, throw your page out of whack when viewed in Explorer. The solution?...

Converging Technologies for Improving Human Performance: Nanotechnology, Biotechnology, Information Technology and Cognitive Science
Converging Technologies for Improving Human Performance: Nanotechnology, Biotechnology, Information Technology and Cognitive Science
This book describes the vast opportunity created by unifying science and integrating technology, and recommends transforming ideas for individuals and society. We stand at the threshold of a new renaissance in knowledge based on the structure and behavior of matter from the nanoscale up to the most complex system yet discovered, the human brain....
Getting Clojure: Build Your Functional Skills One Idea at a Time
Getting Clojure: Build Your Functional Skills One Idea at a Time

Behind every programming language lies a vision of how programs should be built. The vision behind Clojure is of a radically simple language framework holding together a sophisticated collection of programming features. Learning Clojure involves much more than just learning the mechanics of the language. To really get...


Protein Nanotechnology: Protocols, Instrumentation, and Applications (Methods in Molecular Biology)
Protein Nanotechnology: Protocols, Instrumentation, and Applications (Methods in Molecular Biology)
This third edition volume expands on the previous editions with updated approaches and techniques used to study protein nanotechnology and the future of nanomaterial compositions. This book is organized into Three Parts: Part One looks at recombinant protein expression in insect cells, and methods to produce molecular motors,...
Learning ShiVa3D Game Development
Learning ShiVa3D Game Development

Get a grip on ShiVa3D mobile game development with this step-by-step, hands-on tutorial

Overview

  • Step-by-step hands-on introduction, perfect for those just getting started in mobile development
  • Use the StoneScript scripting language to handle object interactions and game events
  • ...
New Masters of Flash: The 2002 Annual
New Masters of Flash: The 2002 Annual

Flash has upped the standard for web motion graphics and has been welcomed with open arms on account of its powerful new ActionScripting capabilities. Following the phenomenal success of New Masters of Flash, the Flash Annual will bring together a new collection of the hottest Flash design talents on the planet, all of whom have...

©2019 LearnIT (support@pdfchm.net) - Privacy Policy