Obesity and diabetes develop as a complex result of genetic, metabolic and environmental factors and are characterized by increased lipogenesis and lipid accumulation in many tissues. Stearoyl-CoA desaturase (SCD) genes are a critical regulator of lipogenesis and catalyzes the synthesis of monounsaturated fatty acids (MUFA), mainly oleoyl- (18:1n9) and palmitoleoyl-CoA (16:1n7). These MUFAs are the major fatty acid substrates for the synthesis of triglycerides, cholesterol esters, wax esters and membrane phospholipids. There are 4 SCD isoforms (SCD1-4) in mice and two (hSCD1 and hSCD5) expressed in humans. At first glance, stearoyl-CoA desaturase enzyme would be considered a housekeeping enzyme because it synthesizes oleate a well-known fatty acid that is abundant in many dietary sources. However numerous studies have shown that SCD is a very highly regulated enzyme that features in so many physiological processes ranging from fat differentiation, carbohydrate and fat metabolism, inflammation and cancer. The editor’s studies using stearoyl-CoA desaturase knockout (SCD1-/-) mice and studies of other investigators using pharmacological approaches to reduce SCD1 expression in mouse tissues have all established that the expression of SCD1 gene isoform represents a key step in partitioning of lipids between storage and oxidation. High SCD expression favors fat storage leading to obesity while reduced SCD expression favors fat burning and leanness. Although these studies clearly illustrated that SCD1 expression is involved in the development of obesity and insulin resistance, questions remain in the elucidation of the mechanisms involved and role of SCD1. This book includes chapters by leading researchers on SCD Genes in the brain, heart, muscle, liver metabolism, Colitis, and more. â
Transforming Business: Big Data, Mobility, and Globalization
A unique perspective of an evolved role for company leadership
Based on the findings of an extensive research project that surveyed more than 5,500 enterprise employees and functional decision makers across the United States and China, Transforming Business: Big Data, Mobility and Globalization explores the influence...
Excel VBA Programming For Dummies (Computer/Tech) Having Excel and just using it for standard spreadsheets is a little like getting the ultimate cable system and a 50” flat panel plasma HDTV and using it exclusively to watch Lawrence Welk reruns. With Visual Basic for Applications (VBA) programming, you can take advantage of numerous Excel options such as: creating new worksheet functions;... The Cosmic Gift An Indian research submarine was exploring the ocean-bed off the coast ofParson's Pygmalion Point, the southern -most tip ofI ndia. Its young Captain, Uttarna, and his crew gazed ent ranced at the strange world under water , strangely lit here and there with many-shaped coral reefs , amidst which innumerable varieties ofcolo urful fish and...
Web Systems Design and Online Consumer Behavior
Web Systems Design and Online Consumer Behavior takes an interdisciplinary approach toward systems design in the online environment by providing an understanding of how consumers behave while shopping online and how certain system design elements may impact consumers' perceptions, attitude, intentions, and actual behavior. This book...
Iminosugars: From Synthesis to Therapeutic Applications
The field of iminosugars is a very exciting area of research. These carbohydrate mimetics
were first imagined and synthesized by chemists in the 1960s before being isolated from
Nature a few years later. Since the discovery of their biological activity as potent glycosidase
inhibitors in the 1970s, iminosugars have been the subject... How to Find a Job on LinkedIn, Facebook, Twitter, MySpace, and Other Social Networks
Classifieds are OUT.
It's time to LINK IN!
Finding the job of your dreams the old way just doesn't happen anymore. If you want great pay, great benefits, and great satisfaction in your career, you must begin social networking.
How to Find a Job on LinkedIn, Facebook, Twitter, MySpace, and...