Home | Amazing | Today | Tags | Publishers | Years | Account | Search 
Structure-based Drug Discovery

Buy
Structure-based Drug Discovery, 9781402044069 (1402044062), Springer, 2007

This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments in technologies that can be used to obtain the 3-D structures. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions.

The last 25 years has seen structure-based drug discovery evolve from an interesting niche activity pursued by a relatively small number of companies to being a fully integrated series of techniques that are part of the core technologies within most large pharmaceutical companies. This increase in popularity has been driven to a large extent by significant technological advances that have allowed the three-dimensional structure of a target protein to be determined in a much shorter time frame. In the 1980’s it could take several years to determine the crystal structure of a key drug target; obtaining structures of bound inhibitors could consume several more months. Today, protein crystal structures may be obtained in months rather than years and subsequent protein/inhibitor complexes often only take weeks (if not days) to solve. Another key factor in the uptake of structure-based discovery methods has been the availability of crystal structures for significantly more proteins at the start of a drug discovery program. This increase in the number of protein structures has also helped the development of improved computational chemistry methods for the prediction of the binding modes of compounds and binding energies.
(HTML tags aren't allowed.)

Big Data Analytics: Disruptive Technologies for Changing the Game
Big Data Analytics: Disruptive Technologies for Changing the Game

Bringing a practitioner’s view to big data analytics, this work examines the drivers behind big data, postulates a set of use cases, identifies sets of solution components, and recommends various implementation approaches. This work also addresses and thoroughly answers key questions on this...

Sustainable Software Development: An Agile Perspective (Agile Software Development Series)
Sustainable Software Development: An Agile Perspective (Agile Software Development Series)
Software development for immediate success and long-term sustainability

Sustainable Software Development brings together principles and practices for building software that is technically superior, delivers exceptional business value, and can evolve rapidly to reflect any change to your business or technical...

Professional Plone Development
Professional Plone Development
This book teaches Plone development best practices, focusing on Plone 3.0. It covers setting up a development environment, customizing Plone's look and feel, creating new content types and forms, connecting to external databases, managing users and groups intelligently, configuring a production-ready server, LDAP authentication, and caching. Aimed...

Twitter Marketing For Dummies
Twitter Marketing For Dummies
Greetings, and welcome to Twitter Marketing For Dummies. You have officially entered into the joyous world of marketing on Twitter. If you want to think about the tool in terms of celebrity, Twitter is the Oprah of social-networking sites. Twitter is huge, both in the number of users and excitement.

This
...
Nagios: System and Network Monitoring
Nagios: System and Network Monitoring

Good system administrators recognize problems long before anyone asks, "Hey, is the Internet down?" Nagios, an open source system and network monitoring tool, has emerged as the most popular solution for sys admins in organizations of all sizes. It's robust but also complex, and Nagios: System and Network Monitoring, 2nd...

The Little Mac Book, Tiger Edition
The Little Mac Book, Tiger Edition
Adopting a back-to-the-basics approach, this best-selling little Mac classic has been revised and overhauled to introduce users to Tiger, Apple's newest version of its revolutionary operating system. In the gentle, friendly, funny style that generations of computer users have come to know and love, author Robin Williams shows readers how to dive...
©2019 LearnIT (support@pdfchm.net) - Privacy Policy