Systems Biological Approaches in Infectious Diseases (Progress in Drug Research)

Systems Biological Approaches in Infectious Diseases (Progress in Drug Research), 9783764375669 (3764375663), Birkhauser, 2006

The much-lamented “innovation gap” often referenced by current authors with respect to drug discovery in the pharmaceutical industry is a sure sign that an era has passed. The reductionist view of disease as the direct consequence of isolated errors of metabolism that could be explained and understood as simple enzyme alterations is a thing of the past. Likewise the na¨Ä±ve view that the system-wide consequences of small molecule interventions could be predicted through simple in vitro assays has become obsolete. Infectious diseases, representing an evolved and complex evolutionary conflict between two life-forms, have been at the vanguard of embracing systems biology concepts due to the obvious failure to cure such diseases by simply studying an invading parasite’s physiology in a test tube. Driven by a virtual renaissance in technology the simple approaches of the previous era have given way to a vast new array of integrative sciences aimed at modeling and understanding the complex and dynamic interactions that characterize real human diseases. Although still struggling for granularity these integrative sciences share a common vision – erasing the differences between disciplines and embracing complexity in tools that offer glimpses of whole biological systems and mesh seamlessly with infinite chemical space.

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