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Volume 3, The Organic Chemistry of Drug Synthesis

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Ihe first volume in this series represented the launching of a trial balloon on the part of the authors. In the first place, wo were not entirely convinced that contemporary medicinal (hemistry could in fact be organized coherently on the basis of organic chemistry. If, however, one granted that this might be done, we were not at all certain that the exercise would engage Ihe interest of others. That book's reception seemed to give nri affirmative answer to each of these questions. The second volume was prepared largely to fill gaps in the coverage and to bring developments in all fields up to a common date - 1976. In the process of preparing those volumes, we formed the habit of scrutenizing the literature for new nonproprietary names as mi indication of new chemical entities in or about to be in the « linic. It soon became apparent that the decreased number of drugs being granted regulatory approval was not matched by a decrease in the number of agents being given new generic Mrtmes, The flow of potential new drugs seemed fairly constant over the years. (For the benefit of the statistician, assignment of new USAN names is about 60 per year.)
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